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FLUORESCENCE MOLECULAR IMAGING - UC

ANRV281-BE08-01 ARI13 July 20062:2 FLUORESCENCE MOLECULAR ImagingVasilis NtziachristosLaboratory for Bio-Optics and MOLECULAR IMAGING , Center for MOLECULAR IMAGING Research,Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114;email: Rev. Biomed. 8:1 33 TheAnnual Review ofBiomedical Engineeringisonline : 2006 byAnnual Reviews. All rightsreserved1523-9829/06/0815-0001$ Wordsoptical IMAGING , optical tomography, FLUORESCENCE , drug discovery,small-animal imagingAbstractThere is a wealth of new fluorescent reporter technologies for tagging of many cellularand subcellular processes in vivo. This imposed contrast is now captured with anincreasing number of IMAGING methods that offer new ways to visualize and quantifyfluorescent markers distributed in tissues. This is an evolving field of IMAGING sciencesthat has already achieved major advances but is also facing important challenges.

Direct Fluorescence Imaging Direct imaging is associated with the administration of an engineered fluorescent ... common practice is the introduction of a transgene (called reporter gene) in the cell. The transgene encodes for a fluorescent protein (FP), which acts as an intrinsically

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  Introduction, Fluorescence

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