Transcription of Glucocorticoid therapy: minimizing side effects - SciELO
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Glucocorticoid therapy: minimizing side effects - SciELO
0021-7557/07/83-05-Suppl /S163 Jornal de PediatriaCopyright 2007 by Sociedade Brasileira de PediatriaREVIEWARTICLEG lucocorticoid therapy : minimizing side effectsCarlos Alberto Longui*AbstractObjective:To describe the main undesirable side effects of Glucocorticoid therapy , mechanisms of action and thenecessary measures to minimize side :Author s experience, supplemented with papers published in :Theprinciplesforminimizingundesirablesi deeffectsofglucocorticoidtherapyinclude: a) only use glucocorticoids if they are essential; b) avoid the use of long-acting glucocorticoids, using short- andintermediate-acting glucocorticoids instead; c) keep treatment as short as possible, since treatment lasting 5 to 7 daysshows fewer side effects and quick recovery of the hypothalamic-pituitary axis; d) use glucocorticoids with local activ-ity preferentially, such as inhaled glucocorticoids; e) use in association with other drugs, especially with other morespecific anti-inflammatory or immune suppressive drugs, promoting a synergistic effect in order to avoid the use ofglucocorticoids or to reduce dosage and duration of Glucocorticoid therapy ; f) indicate the minimum effective dose,respecting individual sensitivity to :In or
space. In the medium and long term, they reduce osteoblas-tic activity, intestinal absorption and renal calcium resorp-tion. Tumors Glucocorticoids can modulate cell ...
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