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Guide to achieving reliable quantitative LC-MS measurements

Guide to achieving reliable quantitative LC-MS measurements Guide to achieving reliable quantitative LC-MS measurements RSC Analytical Methods Committee First Edition 2013. Editor Mike Sargent Contributors Ashley Sage Acknowledgements Celine Wolff This Guide has been prepared with the Chris Mussell assistance of members of the AMC Mass Spectrometry Sub-Committee. David Neville Publication of the draft Guide with minor corrections was approved by the AMC at Gwyn Lord its meeting on 15 November 2013. Mansoor Saeed Production of this Guide was in part Rakesh Lad funded by the UK National measurement System. Ruth Godfrey We are grateful to Agilent Ltd for Simon Hird permission to reproduce Figures , and Gareth Brenton for Figure Vicki Barwick First Edition 2013 This publication should be cited as: ISBN 978-0-948926-27-3. M. Sargent (Ed.), Guide to achieving reliable quantitative LC-MS measurements , RSC Analytical Methods Committee, Copyright LGC Limited 2013 2013.

subjects that need to be considered when using LC-MS for accurate and reliable quantitation, i.e . measuring precisely and accurately how much of an analyte is present in a sample. Quantitative LC-MS Guide, 1 st Ed. 2013 Page 2

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