Transcription of Guidelines on Genetic Evaluation and …
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Guidelines on Genetic Evaluation and …
Nature publishing group PRACTICE Guidelines 1 2014 by the American College of Gastroenterology The American Journal of GASTROENTEROLOGYsee related editorial on page x Colorectal cancer (CRC) is a major American health problem that ranks as the second leading cause of cancer death aft er lung cancer. In the United States, approximately 143,000 new cases are diagnosed each year, and 51,000 Americans die annually from this disorder ( 1 ). Th e cause of CRC is multifactorial, with environment and inheritance playing varying roles in diff erent patients ( 2 ). Approxi-mately 70 80 % of patients with CRC seem to have sporadic dis-ease with no evidence of an inherited disorder. In the remaining 20 30 % , a potentially defi nable inherited component might be causative ( 3 ). Lynch syndrome (LS), an autosomal dominant condition, is the most common cause of inherited CRC, accounting for about 3 % of newly diagnosed cases of colorectal malignancy ( 4 8 ).
The American Journal of GASTROENTEROLOGY VOLUME 104 | XXX 2014 www.amjgastro.com 2 Giardiello et al. METHODOLOGY the American Gastroenterological Literature review A systematic computer-aided search of …
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