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HIGHLIGHTS OF PRESCRIBING INFORMATION ...

1. HIGHLIGHTS OF PRESCRIBING INFORMATION ------------------------------- CONTRAINDICATIONS ------------------------------ These HIGHLIGHTS do not include all the INFORMATION needed to use None. (4). VERZENIO safely and effectively. See full PRESCRIBING INFORMATION for VERZENIO. ------------------------ WARNINGS AND PRECAUTIONS ----------------------- Diarrhea: Instruct patients at the first sign of loose stools to initiate VERZENIO (abemaciclib) tablets, for oral use antidiarrheal therapy, increase oral fluids, and notify their Initial Approval: 2017 healthcare provider.

Refer to the Full Prescribing Information for coadministered aromatase inhibitor or fulvestrant for dose modificationsand other relevant safety information. Dose Modificationfor Use with Strong and Moderate CYP3A Inhibitors Avoid concomitant use of the strong CYP3A inhibitor ketoconazole.

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