Transcription of International Normalized Ratio (INR)
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The Relationship of the International Normalized Ratio (INR) to the prothrombin time (PT) By: William DePond MD, President and Chief Medical Officer MEDLAB In 1983, it was determined that patients receiving long-term anticoagulant therapy may be subject to unnecessary risks of bleeding or thromboembolism because of variability in the commercial thromboplastins used to determine prothrombin time (PT) and consequent uncertainty about the actual intensity of anticoagulation. The accuracy of the PT was noted to be system-dependent showing variations in results due to marked variability in the response of commercial thromboplastin reagents to clotting factors (II, VII, X).
The Relationship of the International Normalized Ratio (INR) to the Prothrombin Time (PT) By: William DePond MD, President and Chief Medical Officer MEDLAB
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