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PROTOCOLS FOR ANTICOAGULANT AND …

PROTOCOLS FOR ANTICOAGULANT AND THROMBOLYTIC THERAPYW ritten by Drs. Evan Shereck and John Wu, Division of Hematology/Oncology/BMT and Alison MacDonald, pharmacistReferences: Antithrombotic Therapy. In: The 2009 Formulary of the Hospital for Sick Children, 11th edition. Toronto 2008. Monagle P et al (eds). Andrew s Pediatric Thromboembolism and Stroke 3rd ed. 2006; BC Decker Inc. Hamilton. Monagle P et al. Antithrombotic therapy in neonates and children: ACCP evidence-based clinical practice guidelines (8th edition). Chest 2008; 133: 887S-968S Malowwany JI, Monagle P, Wu J et al. Enoxaparin for neonatal thrombosis: A call for a higher dose for neonates. Thrombosis Research 2008; 122: : protocol for heparin for warfarin for enoxaparin for systemic thrombolytic Information Sheet ..pageWarfarin Information Information sheet for thrombolytic for ANTICOAGULANT and Thrombolytic Therapy 1 protocol FOR HEPARIN THERAPY(for patients > 1 month of age) Always obtain baseline PT/INR, APTT, CBC and fibrinogen before starting therapy Once APTT is in the therapeutic range, repeat APTT daily; CBC and platelets are to be checked twice weeklyLOADING DOSE: 75 units/kg (maximum: 5000 units/dose)-infuse IV over 10 minutes by syringe pumpINITIAL MAINTENANCE DOSE:< 1 year of age:28 units/kg/hr> 1 year of age:20 units/kg/hrAdolescents and adults18 units/kg/hr (maximum 1000 units/hr)Ob

PROTOCOL FOR HEPARIN THERAPY (for patients > 1 month of age) • Always obtain baseline PT/INR, APTT, CBC and fibrinogen before starting therapy

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