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Introduction to Interrupted Time Series Analysis

Interrupted Time Series Analysis for Single Series and Comparative Designs:Using Administrative Data for Healthcare Impact AssessmentJoseph M. Caswell, AnalystInstitute for Clinical Evaluative Sciences (ICES) North and Epidemiology, Outcomes & Evaluation ResearchHealth Sciences North Research Institute (HSNRI)Northeast Cancer CentrePresentation Overview Quasi-experimental research Interrupted time Series (ITS) ITS single Series with example ITS comparative with example Autocorrelation Adjusting standard errors (SE) in SAS Guide and macroQuasi-Experimental Research Experimental research: Gold-standard is randomized controlled trial (RCT) , drug trials (random assignment to treatment and placebo groups) Treatment and control groups balanced on baseline measures Can be time-consuming, expensive, and even unethical ( , withholding care) Quasi-experimental research.

– Various statistical methodologies for observational studies (i.e., propensity scores, ITS, instrumental variables, etc) Observational Studies • Administrative data: – Routinely collected by hospitals and other healthcare facilities – Great source for conducting observational health studies

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