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Introduction to Multivariate Genetic Analysis
Introduction to Multivariate Genetic AnalysisMeike Bartels, Hermine Maes, Elizabeth Prom-Wormley and Michel NivardAim and RationaleAim:to examine the source of factors that make traits correlate or co-varyRationale:Traits may be correlated due to sharedgenetic factors (A) or shared environmental factors (C or E)Can use information on multiple traits from twinpairs to partition covariation into Genetic and environmental componentsExample 1 Why do traits correlate/covary?How can we explain the association?Additive Genetic factors (rG)Shared environment (rC)Non-shared environment (rE)ADHDE1E2A1A2 A112 IQrGC1C2rC111111rE C112 A222 C222 E112 E222 Example 2 Associations between phenotypes over timewDoes anxiety in childhood lead to depression in adolescence?
Introduction to Multivariate Genetic Analysis Meike Bartels, Hermine Maes, Elizabeth Prom-Wormley and Michel Nivard. Aim and Rationale Aim: to examine the source of factors that make traits correlate or co-vary Rationale: Traits may be correlated due to …
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