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Liquid-liquid extraction combined with high …

*Correspondence: P. P. Maia, Laborat rio de An lises Toxicol gicas, Departa-mento de An lises Cl nicas e Toxicol gicas, Universidade Federal de Alfenas, Rua Gabriel Monteiro da Silva, 700, - Alfenas - MG, Brazil. E-mail: Journal of Pharmaceutical Sciencesvol. 47, n. 2, , 2011 Liquid-liquid extraction combined with high performance liquid chromatography-diode array-ultra-violet for simultaneous determination of antineoplastic drugs in plasmaAnanda Lima Sanson1, Su llen Cristina Renn Silva1, Matheus Coutinho Gon alves Martins1, Alexandre Giusti-Paiva2, Patr cia Penido Maia1*, Isarita Martins11 Faculty of Pharmacy, Laboratory of Toxicological Analysis, Federal University of Alfenas, 2 Institute of Biomedical Sciences, Federal University of AlfenasA Liquid-liquid extraction (LLE) combined with high-performance liquid chromatography-diode array detection method for simultaneous analysis of four chemically and structurally different antineoplastic drugs (cyclophosphamide, doxorubicin, 5-fluorouracil and ifosfamide) was developed.

Liquid-liquid extraction combined with high performance liquid chromatography-diode array-ultra-violet 365 MATERIALS AND METHODS Instrumental and operating conditions

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