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MICROBIAL DEATH - vency

1 MICROBIAL DEATH Antonio Casolari I. A. Microorganisms and Lethal B. Shape of Survivor Curves ..2 II. Single Hit A. Heat Inactivation 1. Thermodynamic a. Maximum Allowable Q10 ..12 b. Minimum Allowable z ..13 c. The Highest Allowable Energy 2. Mechanisms and B. Radiation C. Chemical D. Theoretical III. Target Theory ..18 A. Inactivation by B. Heat Inactivation ..19 C. Limitations of the Theory ..20 IV. Continuously Decreasing DEATH Rate Curves ..20 A. Experimental B. Theoretical C. Mathematical D. Evidence Against Suggested V. Approach to a General Model ..24 A. Heat Inactivation ..24 1.

3 The semilogarithmic plot of survivor curves may have various shapes such as convex, sigmoid, concave, or linear (Figure 1). Different shapes can be obtained: (1) under identical experimental conditions with different

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