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Myers Protective Groups – Silicon-Based Protection …

RO Sii-Pri-Pri-PrRO SiEtEti-PrRO SiCH3CH3CH3 ROHROHOSiOSiOi-Pri-Pri-Pri-PrRRRO SiCH3CH3t-BuRO SiEtEtEtRO SiCH3CH3i-PrRO SiPhPht-BuORORSit-But-BuChem 115 Protective Groups Silicon-Based Protection of the Hydroxyl GroupMyersGeneral Reference:Greene, T. W.; Wuts, P. G. M. Protective Groups In Organic Synthesis, 3rd ed. John Wiley & Sons: New York, Silyl Ether Protective Groups :Trimethylsilyl (TMS)Triethylsilyl (TES)Triisopropylsilyl (TIPS)Dimethylisopropylsilyl (IPDMS)Diethylisopropylsilyl (DEIPS)t-Butyldimethylsilyl (TBS)t-Butyldiphenylsilyl (TBDPS)Di-t-butyldimethylsilylene (DTBS)Tetraisopropyldisilylene (TIPDS)General methods for the formation of silyl ethers:R'3 SiCl imidazole, DMFROSiR'3 ROSiR'3R'3 SiOTf 2,6 lutidine, CH2Cl2 Corey, E.

Myers Protective Groups – Silicon-Based Protection of the Hydroxyl Group Chem 115 General Reference: Greene, T. W.; ... Hydrofluoric acid Tris(dimethylamino)sulfonium difluorotrimethylsilicate (TASF) ... • The protecting group is introduced using thiocarbonyldiimidazole followed by treatment with

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