Transcription of Neplanocin A - jbc.org
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Neplanocin A - jbc.org
THEJOURNAL OF BIOLOGICAL CHEMISTRY Vol. 259, No. 7, Issue of April 10, pp. 4353-4358, 1984. 0 1984 by The American Society of Biological Chemists, Inc. Printed in A . Neplanocin A. A POTENT INHIBITOR OF S-ADENOSYLHOMOCYSTEINEHYDROLASE AND OF VACCINIA VIRUS. MULTIPLICATIONINMOUSE L929 CELLS*. (Received for publication, November 14,1983). Ronald T. Borchardt, BradleyT. Keller, and Usha Patel-Thombre From the Departments of Biochemistry and Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas 66045. Neplanocin A, a novel cyclopentenyl analogof aden- AdoMet-dependent methylation reactions (5, 6). As a conse- osine, is a naturally occurring antibiotic which exhibits quence of inhibiting AdoHcy metabolism cellularmethylation significant antitumor activity against L12 10 leukemia reactions are perturbed, many of which are required formain- in mice (Yaginuma, S., Muto, N., Tsujino, M., Sudate, tenance of the normal metabolic integrity of the cell. Y., Hayashi, M., and Otani, M.)
4354 Antiviral Action of Neplanocin A HOCHL, yy Pl OH OH FIG. 1. Structure of neplanocin A. units of intestinal adenosine deaminase. The reaction was started by the addition of AdoHcy hydrolase and incubated for 5 min at 37 "C.
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