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Neuronal cell types

MagazineR497 PrimerNeuronal celltypesRichard H. MaslandIdentifying the functionallydistinct types of neuron is centralto any bottom-up understandingof how the brain works. Thedifferent cell types are the brain selementary computationalelements the components fromwhich the larger machine ismade. We have known of somecell types for more than acentury, but the coverage hasbeen spotty and anecdotal. Thisis changing: it is now possible toassemble more or less completeinventories of cell types thebrain s parts list, upon which allunderstandings of brain recognition that neuronsare distinct functional entitieswas the first great contribution ofneurobiology s founding father,Santiago Ramon y Cajal, whocould make that leap because hehad a method, the Golgi stain,which shows individual neuronsin spectacular isolation from theirneighbors.

Increasingly, cell types can be distinguished by their expression of genes and/or proteins. Occasionally they are first distinguished by characteristic patterns of electrical activity. But the commonest way is the shape of the cell. This is not only because the shapes of neurons are pretty — which to the trained eye they are — nor is cell shape

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