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neurosarcoidosis: guidance for the general …

293 Views and ReViewsneurosarcoidosis: guidance for the general neurologistNeurosarcoidose: orienta es para o neurologista geralL via Almeida Dutra, Pedro Braga-Neto, Ricardo Ara jo Oliveira, Jos Luiz Pedroso, Agessandro Abrah o, Orlando Graziani Povoas BarsottiniSarcoidosis is an inflammatory multisystem disorder of unknown etiology with a worldwide distribution that can af-fect lungs, lymphatic system, skin, liver, eyes, and nervous sys-tem1. We owe the first recorded and illustrated description of sarcoidosis to Jonathan Hutchinson in 1878, when he report-ed a patient with a dermatologic disease, which comprised purplish, symmetric, and non-tender skin plaques, initially considered a manifestation of gout2. The term sarcoidosis comes from histological studies performed by Cesar Boeck, in 1899, who described pathological findings of skin lesions that resembled those of sarcoma, which he called sarkoid or sarcoma-like 3.

Dutra LA et al.Neurosarcoidosis 295 some authors believe that cytokines and immune factors may also play a role in nerve injury 17.Peripheral neuropathy may be

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