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PFIZER INC.

UNITED STATES SECURITIES AND EXCHANGE COMMISSIONW ashington, 20549 FORM 10-K(Mark One) ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2020 TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from toCommission file number 1-3619 PFIZER INC.(Exact name of registrant as specified in its charter)Delaware13-5315170(State or other jurisdiction of incorporation or organization)( Employer Identification Number)235 East 42nd Street, New York, New York 10017(Address of principal executive offices) (zip code)(212) 733-2323(Registrant s telephone number, including area code)Securities registered pursuant to Section 12(b) of the Act:Title of each classTrading Symbol(s)Name of each exchange on which registeredCommon Stock, $.05 par valuePFENew York Stock Notes due 2022 PFE22 New York Stock Notes due 2027 PFE27 New York Stock ExchangeSecurities registered pursuant to Section 12(g) of the Act: NoneIndicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act.

ALK anaplastic lymphoma kinase ... LIBOR London Interbank Offered Rate Lilly Eli Lilly & Company LOE loss of exclusivity MCO managed care organization mCRC metastatic colorectal cancer mCRPC metastatic castration-resistant prostate cancer mCSPC metastatic castration-sensitive prostate cancer mRNA messenger ribonucleic acid

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