Transcription of Production and Purification of mRNA
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Production and Purification of mRNA
SUPPLIER SIDE. Production and Purification of mRNA. Tomas Kostelec, Rok Sekirnik, An e Martin i Celjar, Kristina prinzar Nemec, Andreja Gramc Livk, Pete Gagnon, and Ale trancar C. OVID-19 has focused a spotlight on the ability of options are available for both capture and polishing, mRNA technology to accelerate vaccine including affinity, anion-exchange, hydrogen-bonding, development and approval (1). That same technology hydrophobic-interaction, and reversed-phase can hasten development and approval of other chromatography methods (4 6). therapeutic classes, including cancer immunotherapy, protein replacement, and gene therapy.
Purification needs to remove the raw materials used for synthesis along with mRNA impurities such as aborted (short) transcripts, double-stranded RNA, and aggregates. Technologies for doing so also are evolving. As protein purification did in the past, the field of mRNA is moving away from precipitation methods toward chromatographic
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