Restricted Cubic Spline for Linearity Test & Continuous ...

4/11/20141 Institute for Clinical Evaluative SciencesInstitute for Clinical Evaluative SciencesSAS HEALTH USER GROUP (HUG)APRIL 11TH, 2014 JIMING FANG, PHDCARDIOVASCULAR PROGRAM, ICESR estricted Cubic Spline for Linearity Test & Continuous Variable Control2 Introduction A Real Study Case at ICESCox Model 1 CoxModel 2 Systolic BP (SBP)Adjusted as dichotomized variable (140+ vs. <140 mmHg)Adjusted as Continuous variableAdjusted HR(Reduced EF vs. Preserved EF) (95%CI: )p= (95%CI: )p= adjusted for baseline characteristics, the survival of heart failure patients with preserved EF is slightly better than those with reduced EFWhen adjusted for baseline characteristics, the survival of heart failure patients with preserved EF is similar tothose with reduced EFCompare 1-year mortality between heart failure patients with reduced ejection fraction (EF) versus those with preserved EF4/11/201423 Dichotomous variables ( , Sex) 1 vs.

• The spline curve was constructed by using a different cubic polynomial curve between each knots. The spline will bend around these knots. • In other words, a piecewise cubic curve is made of pieces of different cubic curves glued together. The pieces are so well matched where they are glued that the gluing is not obvious. Splines –

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  Cubic, Spline, Cubic splines

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