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RETROSYNTHETIC ANALYSIS

RETROSYNTHETICANALYSIS1 RetrosyntheticAnalysis and Synthetic PlanningDefinitions2 Retrosyntheticanalysisisatechniqueforpla nningasynthesis,especiallyofcomplexorgan icmolecules,wherebythecomplextargetmolec ule(TM)isreducedintoasequenceofprogressi velysimplerstructures(retrons)alongapath waywhichultimatelyleadstotheidentificati onofasimpleorcommerciallyavailablestarti ngmaterial(SM) :16 AMSynthetic PlanningLinear Synthesis3 Inlinearsynthesis, :16 AMSynthetic PlanningConvergent Synthesis4 Inconvergentsynthesis, 5 ConsidertheretrosyntheticanalysisofMusca lure,thepheromoneofthedomestichousefly, :16 AMRetrosyntheticAnalysis :16 AMSynthetic ,butmostimportantly, :16 AMSynthetic Planning8 Comparingthetwosyntheticpathwaysshowstha twhiletheWittigrouteisconvergent, Planning9 Retrosyntheticanalysisandsyntheticplanni ngrequirestraining(knowledgeofchemistry) andexperienc

Retrosynthetic Analysis and Synthetic Planning Definitions 2 Retrosynthetic analysis is a technique for planning a synthesis, especially of complex organic molecules, whereby the complex target molecule (TM) is reduced into a sequence of progressively simpler structures (retrons) along a pathway which ultimately leads to the identification

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