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PROTECTING GROUPS IN ORGANIC SYNTHESIS

PROTECTING GROUPS IN ORGANIC SYNTHESIS1 Challenges in ORGANIC :56 PMProtecting GROUPS : A Necessary Evil3 Note,however, :56 PMProtecting GROUPS in ORGANIC SynthesisWhat is a PROTECTING group ?Aprotectinggroup(PG)isamolecularfr ameworkthatisintroducedontoaspecificfunc tionalgroup(FG) :56 PMQualities of a Good PROTECTING group in ORGANIC Synthesis5 Agoodprotectinggroupshouldbesuchthat:(a) Itshouldbereadily,butselectivelyintroduc edtothedesiredfunctionalgroupinapoly-fun ctionalmolecule.(b)Itshouldbestable/resi stanttothereagentsemployedinsubsequentre actionstepsinwhichthegroupbeingmasked(pr otected)isdesiredtoremaindeactivated(pro tected).(c) :56 PMProtecting GROUPS in ORGANIC :56 PMProtecting GROUPS for :(a)Silylether PROTECTING GROUPS (b) Acetalprotecting groupsThese protections replace the acidic proton on an alcohol with an unreactive ether GROUPS for AlcoholsFormation81:56 PMProtecting GROUPS for AlcoholsExampleTert-Butyldimethylsilyl ethers (TBDMS)91:56 PMProtecting GROUPS for Alcohols(SilylProtecting GROUPS )CleavageFluoride sources:Tetrabutylammonium fluoride, Bu4N+F-(TBAF)Pyridine-HFHydrofluoric acid (HF)Ammonium fluoride NH4+F-101:56 PMProtecting GROUPS for Alcohols(SilylProtecting GROUPS )Synthetic Applications of Silyl PROTECTING Groups111:56 GROUPS for Alcohols(SilylProtecting GROUPS )Synthetic Applications of Silyl PROTECTING :56 PMProtecting GROUPS for Alcohols(Benzyl ether PROTECTING Grou)

Protecting Groups in Organic Synthesis 6 ... Acetal Protecting Group Acid catalysed hydrolysis (dilute HCl or AcOH / H 2 O or TFA/ H 2 O or p- ... Protecting Groups for Amino Groups (Carbamate Protecting Groups) Formation Tert-Butyloxycarbonyl Protecting Group (BOC) 1:56 PM 26 Example.

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  Group, Acid, Synthesis, Protecting, Organic, Amino, Protecting groups, Amino groups, Protecting groups in organic synthesis

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