Transcription of Selected Problems in Diagnosis Background to Thyroid …
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Selected Problems in Diagnosis Background to Thyroid …
1 Challenges in the Diagnosis of Thyroid Cancer An UpdateWilliam C. Faquin, , , Head and Neck PathologyMassachusetts General Hospital & Massachusetts Eye and Ear InfirmaryBoston, MASpeaker DisclosureNo Dislosuresto Faquin, , Problems in Diagnosis *Min. invasive follicular carcinoma* Variants of papillary Thyroid carcinoma * Poorly differentiated Thyroid carcinoma THYROIDB ackground to Thyroid Neoplasia2 Most common malignancy of endocrine system Annual incidence = 122,000 cases worldwide Young and middle-age adults More common in women (2-4x; 1:120 risk in ) >90% 10 year survivalTHYROID CARCINOMAThe Overdiagnosis of Thyroid CarcinomaAhn et al N Engl J Med (2014)15X increaseAggressive Thyroid Cancer Less focus on malignant vs benign (NIFT) More focus on identifying aggressive forms of Thyroid cancer How to define aggressive Thyroid carcinoma?
Selected Challenges in the Diagnosis of Papillary Thyroid Carcinoma PAPILLARY THYROID CARCINOMA 70-80% of thyroid carcinomas Indolent (although certain variants are aggressive) - <6.5% mortality Young to middle-aged (20-50 years) Women:men (4:1) Prior radiation exposure, Hashimoto thyroiditis, 4-fold increase among offspring of affected
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