Simulated Biological Fluids with Possible …

Dissolution Technologies | AUGUST 201115e-mail: Biological Fluids with Possible Application in Dissolution TestingMargareth R. C. Marques1,*, Raimar Loebenberg2, and May Pharmacopeia, 12601 Twinbrook Parkway, Rockville, MD 20852, USA2 Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6J 2L7 ABSTRACTThis literature review is a compilation of the composition and, in most cases, the preparation instructions for Simulated Biological Fluids that may be used as dissolution media in the evaluation of dissolution profiles and amount of drug released from pharmaceutical dosage forms. The use of Simulated Biological Fluids can give a better understanding of the release mechanisms and Possible in vivo behavior of a product and enhance the predictive capability of the dissolution testing.

Dissolution Technologies | AUGUST 2011 15 e-mail: mrm@usp.org Simulated Biological Fluids with Possible Application in Dissolution Testing Margareth R. C. Marques1,*, Raimar Loebenberg 2, and May Almukainzi

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