THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, …
Jan 11, 2022 · 1 The near-simultaneous results published by these groups confirm that a person of ordinary skill in 2 the art (“POSA”) would have readily understood how to apply CVC’s system in eukaryotic cells. 3 The question posed at the time was not whether CRISPR-Cas9 would function in eukaryotes—it
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, …
patentdocs.typepad.comJan 13, 2022 · Sigma Application 15/456,205, claim 31. CVC Application 15/981,807, claim 156 or Sigma Application 15/456,205, claim 33. 3 This substitution changes Sigma’s half of the count to its involved dependent claim 33, 4 which recites “wherein the guide RNA is a single molecule,” but is otherwise identical to the 5 current Count.
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, …
patentdocs.typepad.comInterference No. 106,132 CVC Substantive Motion 4 ii Appendix 6: Claim Chart Comparing the ’716 Patent’s Claims 2-4, 11, 14, and 21-22 to
Paper No. Filed February 18, 2022 Filed on behalf of ...
patentdocs.typepad.com12 encompass both single-molecule guide RNA (“sgRNA”) and dual-molecule guide RNA 13 (“dgRNA”), as revealed by CVC’s challenges to Sigma’s sgRNA proofs made by CVC’s 14 exclusive licensee in EPO opposition proceedings. Moreover, Sigma’s more comprehensive
UNITED STATES PATENT AND TRADEMARK OFFICE …
patentdocs.typepad.comUNITED STATES PATENT AND TRADEMARK OFFICE BEFORE THE PATENT TRIAL AND APPEAL BOARD THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF ... Ex. 2468, ¶¶ 277-282; MF14. In the early 2000s, well before 2012, ZFNs had been used for 16 site-specific, programmable gene editing to accomplish genome modifications in eukaryotic cells.
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