Transcription of 学位論文の内容の要旨 - tmd.ac.jp
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学位論文の内容の要旨 - tmd.ac.jp
The Amount of Avian Antigen in Household Dust Predicts the Prognosis . of Chronic Bird-related Hypersensitivity Pneumonitis .. chronic bird-related hypersensitivity pneumonitis:chronic BRHP .. BRHP. 2011 7 2014 6 BRHP .. 11 12 . 5 2 .. Craig ELISA .. Curtis ELISA . bird-related hypersensitivity pneumonitis:BRHP . ELISA . BRHP BRHP .. BRHP . forced vital capacity: FVC 10% . - 1 - .. 1 . 1 FVC .. 40 m Dustream Collector . 100mg 4ml PBST 2 . 500G 5 40 m . -20 .. BALB/c pigeon dropping extracts: PDE . ELISA PDE . 2 .. Kuramochi PDE Day1 15 29 Freund's complete adjuvant PDE Day58 -80 . IgG . ELISA . PDE ELISA . BSA PDE .. HRP 450nm . PDE 1g g .. PRISM SPSS U.. ROC AUC BRHP .. p . - 2 - .. 2011 7 2014 6 180 BRHP. 59 8 28. 23 11 12 .. 2 FVC . 12 7 . A 11 4 12 2 .. p= . ROC . 2 ROC AUC . g/dust 1g . BRHP . FVC binary 5 .. BRHP . 9 14 . 24 . 36 9 5 14 3 . 5 4 3 2 2 . 2 .. BRHP .. bloom . PDE . - 3 - boom bloom .. BRHP .. limitation .. BRHP .. - 4 - . 4892 .. (chronic bird-related hypersensitivity pneumonia: chronicBRHP).
- 2 - 上低下する群を悪化群とし、それ以外を安定群とした。診断前にステロイドが導入されている患 者は呼吸機能に影響を与えるものと判断したため除外した。
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