Transcription of Type 2 Diabetes
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Type 2 Diabetes
Type 2 DiabetesEtiology and reversibilityROYTAYLOR,MD,FRCPR eversal of type 2 Diabetes to normalmetabolic control by either bariat-ric surgery or hypocaloric diet allowsfor the time sequence of underlying path-ophysiologic mechanisms to be reverse order, the same mechanisms arelikely to determine the events leading to theonset of hyperglycemia and permit insightinto the etiology of type 2 Diabetes . Within7 days of instituting a substantial negativecalorie balance by either dietary interven-tion or bariatric surgery, fasting plasmaglucose levels can normalize. This rapidchange relates to a substantial fall in liver fatcontent and return of normal hepatic in-sulin sensitivity. Over 8 weeks,first phaseand maximal rates of insulin secretionsteadily return to normal, and this changeis in step with steadily decreasing pancre-atic fat content. The difference in timecourse of these two processes is information on the intracellulareffects of excess lipid intermediaries ex-plains the likely biochemical basis,which simplifies both the basic under-standing of the condition and the con-cepts used to determine appropriatemanagement.
Type 2 Diabetes Etiology and reversibility ROY TAYLOR, MD, FRCP R eversal of type 2 diabetes to normal metabolic control by either bariat ...
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