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Universality and predictability in molecular …

COGEDE-1039; NO. OF PAGES 10 Please cite this article in press as: Nourmohammad A, et al.: Universality and predictability in molecular quantitative genetics, Curr Opin Genet Dev (2013), and predictability in molecular quantitative geneticsArmita Nourmohammad1,3, Torsten Held2,3and Michael La ssig2 molecular traits, such as gene expression levels or proteinbinding affinities, are increasingly accessible to quantitativemeasurement by modern high-throughput techniques. Suchtraits measure molecular functions and, from an evolutionarypoint of view, are important as targets of natural selection. Wereview recent developments in evolutionary theory andexperiments that are expected to become building blocks of aquantitative genetics of molecular traits.

spirit of classical quantitative genetics, these models assume fast recombination between the trait loci, which resultsin completelinkage equilibrium[45,26,30,31,33 ].

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