Nitrosamine Impurities Application Guide
nitrosamines have been found in sartan drugs, a class of medications used to treat high blood pressure and heart failure, prompting recalls of angiotensin receptor blockers (ARBs)—valsartan, losartan, and irbesartan—which were contaminated with N-Nitrosodimethylamine (NDMA) and N-Nitrosodiethylamine (NDEA), two carcinogenic impurities.
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