TDI SDS改訂 2016.6.1最終版 - urethane-jp.org

1 1 1 1993 03 31 2016 06 01 ( Toluene diisocyanate ( ) No (( ) 1 2 2A 1 2 2 2016 06 01 1 3 3))

2 / 3 3 2016 06 01 CAS No 98 (3)-2214 26471-62-5 2,4- 80 (3)-2214 584-84-9 2,6- 20 (3)

3 -2214 91-08-7 54 6 29 2,4- 80 2,6- 20 15 ( ) TDI (1) (2) (3) (4) 4 4 2016 06 01 (5) TDI 90 95 5 10 2 8.

4 TDI 8. TDI 10 30 C 10 5 5 2016 06 01 8 ppm

5 TWA ppm mg/m3 8) C ppm mg/m3 ACGIH TWA ppm 9) STEL ppm JIS T 8155 JIS T 8153 9 pH C 251 C 135 C (118 C) (150 C)vol hPa(20oC) 6 =1 25 C / log Pow = (2,4- 80 2,6- 20 ) 3 mPa s (25 C) 10 TDI ( ) 6 6 2016 06 01 11 LD50 5840 mg/kg (Wazeter 1964a11)) 7500 mg/kg (CERI 199812)) LD50 9400 mg/kg (Wazeter 1964b13)) GHS 25 C TDI 160mg/m3(22ppm) TDI 25 C LC50(1hr)

6 470mg/m3(66ppm)(Doe and Horspool 198014)) LC50(6hr) 100 140mg/m3(14 19ppm)(Mackay 199215)) 1 25 C TDI 160mg/m3(22ppm) LC50 Duprat et al. 197616) Knapp and Baker 1974a,b17),18) Woolhiser et al. 199819) EU Risk Phrase R38 2 Duprat et al. 197616) Knapp and Baker 197417),18) Woolhiser et al. 199819) EU Risk Phrase R36 irritant 2A (CERI hazard data collection 97-20 199812), WHO 198720), DFG 200321), ACGIH 200422), ACC 200423), Botham et al. 198824), Karol 198325), Pauluhn and Mohr 199826)) EU Risk Phrase R42 1 (CERI hazard data collection 97-20 199812), WHO 198720), DFG 200321), ACC 200422), van Och et al.

7 200027), Zissu et al. 199828)) EU Risk Phrase R43 1 (ACC 200423) Seel et al. 199929) Mackay 199215) Benford and Riley 198830) Loeser 198331)) Loeser 198331 ) DHHS NTP 198632 (DHHS) (Dieter et al. 199033), Schulz 198534) ACGIH 200422 A4 IARC 199935 2B EU Risk Phrase R42 TDI Tyl et ,b36 ,37) Shiotsuka 198738 Weyel et ) Sangha and Alarie197940) 7 7 2016 06 01 (Henschler 196241)) 3 3 1 Ott(2002)42) Ott,Diler and Jolly(2003)43) GHS(UNECE 200344))

8 MDI 1 12 OECD202 EC50(48hr) mg/ (Tadokoro et al. 199745)) EU Risk Phrase R52 3 OECD211 NOEL(21day) mg/ (Cerbelaud et al. 199746)) 13 TDI 14 2078.

9 156 15 TDI TDI 57 30 TDI 8 8 2016 06 01 57 2 57 3 TDI 2,6-TDI 326 TDI 75 2 35 1 2 4 PRTR TDI 4 3 2,3 1 194 1 TDI 1 15 1.

10 2005 2. (2014) 3. 2015 4. (TDI) 1996 5. Woolrich, ; , 43, 89-97 (1982) 6. Duncan,B., et al.; Am , 23, 447-456 (1962) 7. IARC Monographs (2006) 8. (2015) 9. TLVs AND BEIs 2015 ACGIH 10. 312 2 5 11. Wazeter, F. X., Keller, J. G., Buller, R. H., and Geil, R. G. (1964a). Toluene diisocyanate (TDI) and polymethylene polyphenylisocyanate (PAPI): acute toxicity studies (LD50) in male albino rats. Unpublished report by the International Research and Development Corporation. 12. CERI (1998). Chemicals Evaluation and Research Institute, Japan. Unpublished data. 13. Wazeter, F. X., Buller, R. H., and Geil, R. G.