Cytochromes P450
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Interactions médicamenteuses, cytochromes P450 et P ...
www.hug.chInteractions médicamenteuses, cytochromes P450 et P-glycoprotéine (Pgp) 1A2 2B6 2C8 2C92C19 2D6 2E1 3A4/5 Pgp1A2 2C19 2D6 3A4/5 1A2 2B6 2C8 2C9 2C19 2D6 2E1 3A4/5 Pgp Substrats des cytochromes P450 et de la Pgp Majeure Mineure ! Métabolite actif acénocoumarol acide méfénamique acide valproïque! agomelatine alfentanil alprazolam amiodarone!
Singulair (Montelukast Sodium)
www.accessdata.fda.govcytochromes P450 3A4 (e.g., ketoconazole, erythromycin) or 2C9 (e.g., fluconazole) on montelukast pharmacokinetics have not been conducted. Based on further. in vitro. results in human liver microsomes, therapeutic plasma concentrations of montelukast do not inhibit cytochromes P450 3A4, 2C9, 1A2, 2A6, 2C19, or 2D6 (see . Drug Interactions). In ...
INTERACTIONS MEDICAMENTEUSES, CYTOCHROMES …
www.hug.chINTERACTIONS MEDICAMENTEUSES, CYTOCHROMES P450 ET P-GLYCOPROTEINE (Pgp) 1A2 2B6 2C8 2C9 2C19 2D6 2E1 3A4/5 PgP 1A2 2B6 2C8 2C9 2C19 2D6 2E1 3A4/5 PgP 1A2 2B6 2C8 2C9 2C19 2D6 2E1 3A4/5 PgP acénocoumarol étravirine pérampanel acide méfénamique everolimus phénobarbital acide valproïque! felbamate phenprocoumone …
NONCLINICAL SAFETY TESTING IN SUPPORT OF …
database.ich.orgCYP Cytochromes P450 . DRF Dose Range-Finding . ePPND Enhanced Pre- and Postnatal Development . FIH First in Human . FOB Functional Observational Battery . GABA Gamma Aminobutyric Acid . GFR Glomerular Filtration Rate . GI Gastrointestinal . HPG Human Pituitary Gonadotropin . ICH International Council for Harmonisation . JAS Juvenile Animal Study
COURS DE PHARMACOCINÉTIQUE
www.recherchecliniquepariscentre.frRéactions de phase I : réactions d’oxydation par les cytochromes P450 (CYP3A4 (50%), 2D6 (15%) et 2C) Réactions de phase II: réactions de conjugaison glucurono, sulfo, glutathion, N-acétyltransferase. • Transporteurs : pompes d’efflux exprimées au niveau de l’intestin, du foie, BHE s’opposent à l’absorption intestinale
Exploring Alcohol’s Effects on Liver Function
pubs.niaaa.nih.gova family of proteins called cytochromes. Some cytochromes, located in a cellu-lar substructure called the endoplas-mic reticulum (see figure in glossary, pp. 93–96), detoxify harmful sub-stances that enter the body. The MEOS oxidizes alcohol to acetalde-hyde by means of a cytochrome called P450 2E1, or CYP2E1, which is found
Alcohol and Medication Interactions
pubs.niaaa.nih.govcytochrome P450 are described in more detail in the section “Alcohol Metabolism in the Liver.” The contribution of stomach (i.e., gastric) enzymes to first-pass alcohol metabolism, however, is controversial. Whereas some researchers have pro-posed that gastric enzymes play a major role in first-pass metabolism (Lim et
El Citocromo P-450
www.medigraphic.comEl Citocromo P450 (CYP-450) es una familia de homo-proteínas presentes en una gran variedad de especies, des-de bacterias hasta mamíferos. Son las enzimas responsa-bles del metabolismo de una gran variedad de xenobióticos (fármacos, pesticidas, esteroides y alcaloides) y de la de-gradación de sustancias producidas por el propio organis-