Transcription of 2．界面活性とミセル形成(p.159-174 p99-104)
1 ( p99-104) ( ) HLB ( ) a. b. c. Griffin HLB (Hydrophilic-Lipophilic Balance)HLB=20Mw/M M Mw HLB=7+ (Mw/Mo) Mo ( )1) (cmc) CH3(CH2)11SO Nacmc= mmol dm-3C12H25O(CH2CH2O)
2 12 Hcmc= mmol dm-3 5-10nm CH2 COOC8H17CH2 COOC8H17SO3Na cmc ( )z z z cmc 3)
3 Z z z z z cmc cmc n cmclog[]cmcBAn= z z z z z z z z z z z z z z z z z z OS coswsoswo = +
4 (p150) emulsion) O/W(Olil in water) W/O(Water in oil) 400nm 10-100nm DHA (p99)
5 LB ( MLV Multi-lamellar vesicle 400-3500nm SUM Small unilamellar vesicle 20-50nm LUV Large unilamellar vesicle 200-100nm Drug Delivery System(DDS) 2 1. HLB 2. 3. cmc cmc 4. cmc 5. 6. 7. 8. 9. 10.)
6 11. (2006). (1995).
