ชนนพร บุญศิริวัฒนกุล ศึกษาแพทย์ปีที่ 6

1 streptococcus suis infection in human . 6.. streptococcus suis .. streptococcus suis .. streptococcus suis systemic infection ..1954 streptococcus suis . meningitis, septicemia, purulent arthritis 14 . streptococcus .. streptococcus suis .. Epidemiology streptococcus suis .. ( . , , , , , , ) ( , , , ) . streptococcus suis . normal flora . streptococcus suis colonize . nasal cavities, tonsils, upper respiratory tract, genital tract, gastrointestinal tract streptococcus suis . 37. serotype serotype . serotype Serotype2 . streptococcus suis serotype2 . molecular technique PCR. streptococcus suis streptococcus suis systemic infection .. Meningitis streptococcus suis meningitis bacterial meningitis.

2 Headache Fever Vomiting Meningeal irritation sign 2-5 . Meningitis streptococcus suis bacteremia . bacterial meningitis streptococcus pneumonia, Nisseria meningitidis streptococcus suis meningitis .. streptococcus suis meningitis High frequency sensorineural hearing loss Profound hearing loss . streptococcus suis meningitis .. vestibular dysfunction . (6-31%) petechiae, purpura, ecchymoses . hemorrhagic bullae skin necrosis purpura fulminans . gangrene . streptococcus suis subacute acute endocarditis . Infective endocarditis streptococcus suis . streptococcus suis meningitis streptococcus suis endopthalmitis,uveitis, acute pyogenic arthritis, spondylodiscitis . streptococcus suis Acute renal failure, Acute respiratory distress syndrome, consumptive coagulopathy Microbiological diagnosis streptococcus suis (Gram positive cocci in pair).

3 streptococcus suis .. streptococcus species Viridan streptococci, Enterococcus faecalis, Aerococcus viridians streptococcus pneumonia . molecular technique PCR. technique detect streptococcus suis serotype2 .. PCR technique detect streptococcus suis .. Treatment and outcome streptococcus suis meningitis . bacterial meningitis . Penicillin, Cephalosporin . Vancomycin streptococcus suis meningitis Bacterial meningitis . Empirical antibiotic treatment cephalosporin Ceftriaxone . Vancomycin .. Pneumococcal meningitis . Ceftriaxone 2 g IV q 12 hr x 14 days . Penicillin G 24 million U IV q 24 hr x 10 days . Streptoccus suis penicillin . ceftriaxone resistance strain Dexamethasone streptococcus suis meningitis morbidity.

4 Mortality .. Randomized controlled trial dexamethasone bacterial meningitis . Dexamethasone IV q 12 hr 4 . 1 6 . Dexamethasone streptococcus suis meningitis . dexamethasone multivariate analysis . 50 corticosteroid .. streptococcus suis . endemic area .. streptococcus suis .. References 1. Lun ZR, Wang QP, Chen XG, Li AX, and Zhu XQ. streptococcus suis: an emerging zoonotic pathogen. Lancet Infect Dis 2007; 7:201 9. 2. Tran Vu Thieu Nga, Ho Dang Trung Nghia. Real-time PCR for detection of streptococcus suis serotype 2 in cerebrospinal fluid of human patients with meningitis. Diagn Microbiol Infect Dis. 2011 August; 70(4-19): 461 467. 3. Hee Jae Huh, Kyoung-Jin Park, Ja-Hyun Jang, Mina Lee, Jang Ho Lee, Yoon Hee Ahn, Cheol-In Kang, Chang-Seok Ki,, and Nam Yong Lee.

5 streptococcus suis Meningitis with Bilateral Sensorineural Hearing Loss. Korean J Lab Med 2011;31:205-211.