Allergens − Immunoglobulin E (IgE) Antibodies

1 MC4091-68rev0521 Page 1 of 9 Single Allergen IgE AntibodyThis test is principally useful to confirm the allergen specificity in patients with clinically documented allergic disease. Therefore, requests for these tests should be made after a careful and comprehensive medical history is taken. Utilized in this manner, a single allergen Immunoglobulin E (IgE) antibody test is cost-effective. A positive result may indicate that allergic signs and symptoms are caused by exposure to the specific IgE AntibodiesProfile TestsA number of related Allergens are grouped together for ordering convenience. Each is tested individually and reported. Sample volume requirements are the same as if the tests were ordered TestsA pooled allergen reagent is used for each panel; therefore, the panel is reported with a single qualitative class result and concentration. The multi-allergen IgE antibody panel, combined with measurement of IgE in serum, is an appropriate first-order test for allergic disease.

2 Positive results indicate the possibility of allergic disease induced by one or more Allergens present in the multi-allergen panel. Negative results may rule out allergy, except in rare cases of allergic disease induced by exposure to a single testing requires less specimen volume and less cost for ruling out allergic response; however, individual (single) allergen responses cannot be identified. In cases of a positive panel test, follow-up testing must be performed to differentiate between individual Allergens in the : Only 1 result is generated for each may be ordered with or without concurrent measurement of total E (IgE)Measurement of the concentration of IgE in serum may be useful in the initial evaluation of patients suspected of having an allergic disease. Serum IgE concentrations greater than mean +2 SD are associated with allergic disease; concentrations greater than the mean +1 SD are suspicious for allergic disease.

3 However, some allergic individuals do not have above-normal concentrations, while some individuals may have elevated total IgE in the absence of clinical allergic disease. Measurement of serum IgE along with the multi-allergen IgE antibody test may offer greater sensitivity for the detection of allergic disease than either test Immunoglobulin E (IgE) Antibodies 2021 Mayo Foundation for Medical Education and ResearchMC4091-68rev0521 Page 2 of 9 Mayo Clinic Laboratories Available Specific IgE Allergies ListingAnimals (Epithelia and Proteins)BOVB ovine Serum AlbuminBDRPB udgerigar DroppingsBFTHB udgerigar FeathersCFTHC anary FeathersCATCat EpitheliumCDROPC hicken DroppingsCHCKC hicken FeathersCSPRC hicken Serum ProteinsCOWCow EpitheliumDOGDDog DanderDUCKDuck FeathersFEEPF erret EpitheliumFINCHF inch FeathersGERBG erbil EpitheliumGOATGoat EpitheliumGOOSG oose FeathersGUING uinea Pig EpitheliumHEPIH amster EpitheliumHORSH orse DanderMOUSM ouse EpitheliumMOSPM ouse Serum ProteinsMOUPM ouse Urine ProteinsPIGEPig EpitheliumPIGFP igeon FeathersREPIIR abbit EpitheliumRSERR abbit Serum ProteinsRUPRR abbit Urine ProteinsRATRat EpitheliumRTSPRat Serum ProteinsRTUPRat Urine ProteinsSHWLS heep WoolTURKFT urkey FeathersAntibioticsAMOXYA moxicillinAMPA mpicillinPBPOP enicillin GPENIVP enicillin VDrugsRACTHA drenocorticotropic Hormone, ACTHINHUI nsulin (Human)

4 TTOXT etanus ToxoidFood DairyALFAA lpha-LactalbuminBLACBeta-LactoglobulinCA SEC aseinCCHZC heese, CheddarMCHZC heese, MoldEGGEgg WhiteYOLKEgg YolkMILKMilkGMILKMilk, GoatMAREMilk, MarePMLKMilk, ProcessedOVALO valbuminOVMUO vomucoidWEGGW hole EggWHEYWheyFood FishANCHA nchovyMUSSBlue MusselCLAMClamCODC odfishCRABCrabCRAYC rayfishHAKEHake, FishHALIH alibutHERRH erringLANGL angust (Lobster)LOBL obsterMACKM ackerelCHUBM ackerel, ChubJMACKM ackerel, JackMEGRM egrimOYSTO ysterPLAIP laiceSALMS almonSARDS ardine (Pilchard)SCALSS callopSHRIS hrimpSOLEFSoleSQUIDS quidSQUIS quid, PacificSWORDS wordfishTROTT routTUNATunaFood FruitAPPLA ppleAPRA pricotAVOCA vocadoBANAB ananaBLACKB lackberryBLUEB lueberryCAROBC arobCHERC herryCCNTC oconutCRANBC ranberryDATEDate, FruitGRAPG rapeGRFRG rapefruitKIWIKiwiLEML emonLIMELimeMANDM andarinMANGOM angoMELNM elonsORNGO rangePAPYP apayaPFRUTP assion FruitPECHP eachPEARPearPERSP ersimmonPNAPP ineapplePLUMPlumRASPR aspberryRECRRed CurrantSTBYS trawberryWMELW atermelonFood GrainsBRLYB arleyBUCWB uckwheatG LTGlutenHOPHop FruitMALTMaltCMILM illet, CommonFMILM illet, FoxtailJMLM illet.

5 JapaneseOATSOatPUSEP umpkin SeedRASER apeseedRICERiceRYERyeSOYS oybeanSBSES ugar Beet SeedSUNFSS unflower SeedWHTW heatFood MeatBEEFBeefCHICC hickenHORMH orse MeatLAMBLambOCTOO ctopusPORKPorkRAMBR abbit MeatTURKT urkeyFood MiscellaneousBYSTB aker s YeastCOCOAC acao/CocoaGELAG elatinGUMGum ArabicGGUMGum GuarLINSL inseedMUSHM ushroomSNAILS nailTEATe aTRAGT ragacanthFood NutsALMA lmondBRAZB razil NutCASHC ashewCNUTC hestnut, SweetMACNTM acadamia NutNUTHH azelnut FoodPEANP eanutPEANTP eanut, IgE with Reflex to Peanut ComponentsPECP ecan FoodPINEPine NutPISTAP istachioB LWWalnut FoodMC4091-68rev0521 Page 3 of 9 Mayo Clinic Laboratories Available Specific IgE Allergies Listing (continued)Food Spices/CondimentsANSEA niseBASLB asilBAYLBay LeafCWAYC arawayCARDC ardamomCHILIC hili PepperCINNC innamonCLOVC loveCORIC orianderCURRC urryDILLDillGARLG arlicGINGG ingerGRFEG reek FennelMACEMaceMARJM arjoramMSTDM ustardNMEGN utmegOREGO reganoPAPRP aprikaPOPSDP oppy SeedSESAS esame SeedTARRT arragonTHYMT hymeVANILV anillaFood VegetablesASPARA sparagusBAMBB amboo ShootGSTBBean, Green StringKIDBNBean, Kidney (Red)BENWBean, WhiteBEETSB eets (Beetroot)

6 BROCB roccoliBSPRB russel SproutCABBC abbageCROTC arrotCALFLC auliflowerCELYC eleryCHXPC hickpeaCORNCorn FoodCUKEC ucumberEGGPE ggplantLENL entilLETTL ettuceOLIVFO live FoodONINO nionPAPRP aprikaPSLYP arsleyGPEAPea, GreenSPOTP otato, SweetPOTAP otato, WhiteSPINS pinachSQUAS quashTOMAT omatoGrassesBAHGB ahia GrassBGRSB arley GrassBERGB ermuda GrassBROMB rome GrassCAGRC anary GrassREEDC ommon ReedCRNPCorn PollenOATCC ultivated OatCRYEC ultivated RyeWHTCC ultivated WheatJOHNJ ohnson GrassJUNEJune GrassMEADM eadow FescueMFOXM eadow FoxtailORCHO rchard GrassREDTRed TopRYEGRye GrassVERGS weet Vernal GrassTIMGT imothy GrassVELVV elvet LeafWRGRWild Rye GrassHouse DustHDGH ouse Dust/Greer LabHDHSH ouse Dust/H-S LabHouse Dust MitesACARA carus siroBTROPB lomia tropicalisDMICD ermatophatoides microcerasDFHouse Dust Mites/Dermatophagoides farinaeDPHouse Dust Mites/Dermatophagoides pteronyssinusEMAYE uroglyphus mayneiGDOMG lycyphagus domesticusLEPDL epidoglyphus destructorTRYPIT yrophagus putrescentiaeInsects VenomsHBVH oneybee VenomWSPVWasp VenomWFHVW hite Faced Hornet VenomYFHVY ellow Faced Hornet VenomYJVY ellow Jacket VenomInsects Whole BodiesBBEETB erlin

7 BeetleBWORB lood WormCOCRC ockroachEHORE uropean HornetFANTFire AntHFSFH orsefly/Stable FlyMSPPM osquito speciesMOTHMothIsocyanateIHDII socyanate HDIIMDII socyanate MDIITDTI socyanate TDIM iscellaneousSMFLS eminal FluidALGALG alactose-Alpha-1,3-Galactose (Alpha-Gal)MUXF3 MUXF3 (Cross-reactive Carbohydrate DeterminantMoldsALTNA lternaria tenuisASPA spergillus fumigatusASPGA spergillus nigerAUPUA ureobasidium pullulansBOTB otrytis cinereaCDABC andida albicans (Monilia)CEACC ephalosporium acremoniumCHGLC haetomium globosumCLADC ladosporiumCURLC urvularia lunataEPURE picoccum purpurascensFUSMF usarium moniliformeHELMH elminthosporium halodesMUCM ucorPENLP enicillium chrysogenumPHMAP homa betaeRHNIR hizopus nigricansSTEMS temphylliumTRVIT richoderma virideTCPTT richophyton rubrumULCHU locladium chartarumUSNUU stilago nuda, Mold Grain RustOccupationalAAMYA lpha-AmylaseCOTTC otton FiberCSEDC ottonseedEOXDE thylene OxideFRMHF ormaldehydeGCBNG reen Coffee BeanGPEPG reen PepperISPGI spaghulaLATXL atexLYSOL ysozymeMAANM aleic AnhydridePAHDP hthalic AnhydrideSILKSilkParasitesANISPA nisakis, ParasiteASCRIA scarisMC4091-68rev0521 Page 4 of 9 Mayo Clinic Laboratories Available Specific IgE Allergies Listing (continued)TreesACAA caciaBCYPBald CypressBECHB eechBETV2 BET v2 (Profilin))

8 BXMPLBox Elder/MapleCEDRC edarJCEDRC edar, JapaneseCEDC edar, MountainCTREC hestnut TreeCTWDC ottonwoodDATREDate TreeDFIRD ouglas FirESYCE astern SycamoreELDRE lderELMElmEUCLE ucalyptusALDRGrey AlderHAZH azelnut TreePCANHH ickory, PecanWHICH ickory, WhiteHBEAHorn BeamLINDL indenMELAIM elaleuca leucadendronMESQM esquiteMULBM ulberryOAKOakOLIVO live TreeAPINPine, AustralianWPINPine, WhitePTREP rivet TreeQPALMQ ueen PalmBIRS ilver BirchSPRUS pruceSGUMS weet GumWALNW alnut TreeASHWW hite AshWILLW illowWeedsCBURC ockleburOXID aisy, Ox-EyeDANDD andelionELDRE lderMARSE lder, Rough MarshEGPLE nglish PlantainFBSHF irebush (Kochia)GLDRG oldenrodLAMQLamb s QuarterLUPNL upinMUGM ugwortNETTN ettlePJUDP arietaria judaicaPOFFP arietaria officinalisRRRPR ough PigweedFRWR agweed, FalseGRWR agweed, GiantSRWR agweed, ShortWRWR agweed, WesternRWEEDRape WeedSORRRed SorrelRUSSR ussian ThistleSCLES caleSUNFS unflowerMC4091-68rev0521 Page 5 of 9 Screening Panels One result per panel selected*Mayo Clinic Laboratories Available Specific IgE Allergies Listing (continued)

9 *A pooled reagent is used to obtain 1 screening result per #1 CatCowDogHorseEPIP2 Epithelia #2 Guinea PigHamsterMouseRabbitRatFETH2 Feather #2 ChickenDuckGooseTurkeyFOOD2 Food FruitAppleBananaPeachPearFOOD4 Food GrainBarleyRiceRyeWheatFOOD8 Food Nut #1 AlmondBrazil NutCoconutHazelnutPeanutFOOD1 Food Nut #2 CashewPecanPistachioWalnutFOOD6 FoodCodfishCow s MilkEgg WhitePeanutSoybeanWheatFDP1 Food Panel 2 CabbagePaprikaSpinachTomatoFOOD7 Food SeafoodBlue MusselCodfishSalmonShrimpTunaGRAS1 Grass #1 June/Kentucky BlueMeadow FescueOrchardRyeTimothyGRAS2 Grass #2 BahiaBermudaJohnsonJune/Kentucky BlueRyeTimothyGRAS3 Grass #3 Cultivated RyeRyeSweet VernalTimothyVelvet LeafHD1 House DustCockroachDermatophagoides farinaeDermatophagoides pteronyssinusHouse Dust/H-S LabMOLD1 MoldAlternaria tenuisAspergillus fumigatusCandida albicans (Monilia)Cladosporium herbarumHelminthosporium halodesPenicillium chrysogenumTREE1 Tree #1 BirchBox Elder/MapleElmOakWalnutTREE3 Tree #3 CottonwoodElmGrey AlderHazelnutWillowTREE4 Tree #4 AcaciaEucalyptusMelaleucaOlivePineWillow WEED1 Weed #1 English PlantainLamb s QuarterMugwortRussian ThistleShort RagweedWEED2 Weed #2 English PlantainLamb s QuarterMugwortScaleWestern RagweedWEED3 Weed #3 English PlantainLamb s QuarterRed SorrelRusian ThistleWEED4 Weed #4 Giant RagweedShort RagweedWestern RagweedMC4091-68rev0521 Page 6 of 9 APGALG lactose-Alpha 1,3-Galactose (Alpha-Gal) Mammalian MeatBeefPorkLambMilkGalactose-Alpha 1,3-Galactose (Alpha-Gal)

10 DAGRD airy and GrainEgg WhiteMilkOatSoybeanWheatEGGPFEgg ComprehensiveWhole EggEgg WhiteEgg YolkOvalbuminOvomucoidEGWTPEgg WhiteEgg WhilteOvalbuminOvomucoidINSECS tinging InsectsHoneybee VenomWasp VenomWhite Faced Hornet VenomYellow Faced Hornet VenomYellow Jacket VenomNEREGN ortheast RegionalOakTimothy GrassJune GrassShort RagweedLamb s QuarterCat EpitheliumDog DanderCladosporiumAlternaria tenuisHouse Dust Mites/ Dermatophagoides farinaeNSIPNon-Seasonal InhalantsCat EpitheliumDog DanderPenicillium chrysogenumCladosporiumAspergillus fumigatusAlternaria tenuisHouse Dust/Greer LabHouse Dust/H-S LabHouse Dust Mites/ Dermatophagoides farinaeHouse Dust Mites/ Dermatophagoides pteronyssinusProfile Tests Individual results are reported for each member of the Clinic Laboratories Available Specific IgE Allergies Listing (continued)RPR2 Respiratory Profile, Region 2, Mid-Atlantic (DC, DE, MD, NC, VA) Immunoglobulin E (IgE)House Dust Mites/ Dermatophagoides pteronyssinusHouse Dust Mites/ Dermatophagoides farinaeCat EpitheliumDog DanderBermuda GrassTimothy GrassJohnson GrassCockroachPenicillium chrysogenumCladosporiumAspergillus fumigatusAlternaria tenuisBox Elder/MapleSilver BirchMountain CedarOakElmCottonwoodPecan HickoryMulberryShort RagweedRough PigweedRed SorrelRPR1 Respiratory Profile, Region 1, North Atlantic (CT, MA, ME, NJ, NH, NY, PA, RI, VT) Immunoglobulin E (IgE)