Allograft Bone Chips and Blocks. Structural …

1 The answer tobone voidsAllograft bone Chips and support for bone bone voidfillerStructural scaffoldValidated safetyBrochure for use outside of the and cortical/cancellous allo-grafts have good osteoconductiveproperties and are very well suited tofill defects in the bony structure. Due totheir natural origin and optimal poro-sity, they are readily remodeled by thehuman body and are replaced by newhost Allograft is a strongbone graft material that can providestructural support to the bony defectwhere synthetic bone graft substitutesare limited. Allograft bone Chips and Blocks aresourced by the Musculoskeletal Trans-plant Foundation (MTF) in the UnitedStates and facilitated through Synthesin selected countries. Founded in 1987,MTF is the largest non-profit muscu-loskeletal tissue recovery organizationin the world. Accredited by the AATB (AmericanAssociation of Tissue Banks). Complies with all FDA regulations re-garding the recovery, processing anddistribution of Allograft tissues.

2 Certified according to ISO 9001 donor selectionEvery donor is screened thoroughly. Ex-clusion criteria for tissue donation in-Natural bone void fillerAllograft bone Chips and support for bone scaffoldValidated safetyCancellous bone Aseptic processing at MTFC ancellous Allograft tissue is slightlyless rigid but still provides structuralsupport to the bony defect ( as com-pared to many synthetic bone graftsubstitutes). Products Cancellous Chips (milled) Cancellous Chips (cut) Cortical/cancellous Chips (50%/50%) Cortical/cancellous Chips (80%/20%) Cancellous blockclude infectious diseases, malignantdiseases, neurological degenerative dis-eases, diseases of unknown aetiologyand exposure to toxic testingAll tissue donors undergo stringentserological testing, including tests forHIV-1, HIV-2, hepatitis B, hepatitis C,syphilis and HTLV-1. HIV and hepatitis Care tested through Nucleic Acid tissue is microbiologically testedbefore and after releaseDonors are only released to processingafter extensive review of all charts andrecords by MTF s Medical Directors,who are all physicians with infectiousdisease or pathology Chips (milled)Cancellous Chips (cut)Cortical/cancellous Chips (cut)Cancellous blockRehydration of Allograft chipsIndicationsThere are different indications that aresuitable for the use of Allograft chipsand blocks: Impaction grafting during femoral oracetabular revisions Filling of bone defects Tibia plateau impression fractures Arthroplasty and revision arthroplasty Posterior spinal fusionsPreparations for useBibliographyAzuma, T et al.

3 (1994) Compressed Allograft Chips for Acetabular Recon-struction in Revision Hip 76(5) , J J et al. (1995) Impaction Graf-ting: Preliminary Report of a NewMethod for Exchange Femoral Arthro-plasty. Orthopedics 18(2):107 of freeze-dried tissue To rehydrate freeze-dried tissue in anacceptable sterile irrigant ( normalsaline or Lactated Ringer Solution) iscommon but not mandatory prior touse. bone Chips do not necessarilyneed to be rehydrated. The decision to rehydrate the freeze-dried cancellous bone prior to trans-plantation should be based upon thesurgeon s preference. Gie, G A et al. (1993) Impacted Cancel-lous allografts and Cement for RevisionTotal Hip Arthroplasty. Journal of Boneand Joint Surgery 75(1):14 , T et al. (1996) Acetabular andFemoral Reconstruction with ImpactedGraft and Cement. Clinic Orthopaedicsand Related Research 323:108 115. To increase the biological propertiesof the implant, the patient's ownblood or bone marrow can be usedto rehydrate the freeze-dried tissue.

4 Optimal performance is achievedwhen rehydration is done at least 30minutes prior to the operation. To process the rehydration, a transferof the Allograft from the plastic trayof the package to a sterile containeris necessary. The Allograft tissue can be cut to thepreferred size after offered Allograft tissue acts asbone void (defect) filler, as structuralgraft, and is suited for trauma, tumorresection and hip and knee though Allograft Chips and blocksprovide Structural support to the bonydefect, these implants are not indicatedfor use in load bearing indications, unless used in conjunction with appro-priate osteosynthesis fixation. Depend-ing on the size, voids of undefinedgeometric shape can be filled withchips. Voids with defined geometricshape can be filled with after impaction grafting Allograft bone Chips and support for bone Allograft bone Chips (freeze-dried)Art. No. Diameter Volume FormMTF-400115 mm 15 cc MilledMTF-400120 mm 30 cc MilledMTF-400125 mm 45 cc MilledMTF-400140 mm 5 cc CutMTF-400145 mm 15 cc CutMTF-400150 mm 30 cc CutMTF-400155 mm 60 cc CutMTF-400160 mm 90 cc CutOrdering informationFacilitated through: SE_122503 AC 70100001 10/2009 Synthes, Inc.

5 Or its affiliates All rights reserved Synthes is a trademark of Synthes, Inc. or its affiliatesCortical/cancellous Allograft bone Chips (freeze-dried)Art. No. Size Volume Ratio cortical/cancellousMTF-400045 mm 30 cc 50%/50%MTF-400046 mm 45 cc 50%/50%MTF-400047 mm 90 cc 50%/50%MTF-400058 mm 60 cc 80%/20%MTF-400053 mm 5 cc 80%/20%MTF-400051 mm 30 cc 80%/20%MTF-400060 mm 90 cc 80%/20%Cancellous Allograft bone block (freeze-dried)Art. No. Size (L W H) VolumeMTF-400291 15 8 20 mm ccMTF-400292 15 10 20 mm ccMTF-400293 15 12 20 mm ccMTF-400281 30 11 11 mm ccMTF-400283 30 13 13 mm ccMTF-400280 30 15 15 mm ccMTF-400288 30 18 18 mm ccMTF-400285 30 25 25 mm cc AC=