Transcription of アポトーシス（apoptosis） 細胞の死の区分 (Kerr …
1 Apoptosis (Kerr ,1972) necrosis 1. 2. 3. 1997 DNA DNA DNA DNA size marker123246369492 ( 1997 DNA 5000 100 / / DNA DNA DNA AP DNA C,A DNA NHHONNHHOCH2 OPOO-OHOONNHHOCH2 OPOO-ONNNNHNHHHOOCH2 OPOO-OOCH2 OPOO-OOHCYTOSINEURASIL GUANINE DNA = 2-3 A:Normal tissue AOM- GNA+ or - B:Tumor AOM+ GNA - C:Tumor AOM + GNA + AI(%) : cells in colonic tissues(Kameue et al.))
2 2004)AI(%) : , (%): S G G DNA . CDC, Cyclin, CKI . G DNA p53 CKI (p21) G DNA Rad 9 M Mad 2 APC cd 25 Chk 1,2 Death signalTNF, Fas L, TRAILBcl-2 Bcl-xLBaxBak
