CONTENTS

1 I CONTENTS . List of participants .. iii Abbreviations .. vii Use of JMPR Reports and evaluations by registration authorities .. xi Report of the 2000 JMPR FAO/WHO Meeting of 1.. 1. Introduction .. 1. 2. General Considerations .. 3. Progress on estimation of acute dietary intake: International estimates of short-term dietary 3. Relevance of food processing questionnaires for JMPR 3. Measures to be taken when estimated dietary intake exceeds the ADI .. 4. Feasibility of establishing maximum residue limits for genetically modified crops and for residue of metabolites .. 6. Minimum data required for establishing maximum residue limits, including import tolerances .. 6. Periodic review of data on residues of compounds currently being re-registered nationally.

2 7. Maintaining the independence of the JMPR decision-making process .. 7. Information required for Good Agricultural Practice .. 9. Harmonisation between JECFA and 10. Establishment of acute reference 10. Summaries of critical end-points .. 11. 3. Dietary risk assessment for pesticide residues in food .. 14. 4. Evaluation of data for establishing values for the acute dietary intake of humans, maximum residue levels, supervised trials median residue levels and daily intakes .. 18. Abamactin (R).. 18. Captan (R,D) ** .. 19. Carbaryl (T) .. 31. Chlormequat (R,D) .. 31. Chlorpropham (T)* .. 40. Chlorpyrifos (R,D) ** .. 45. DDT (T, R, D).. 59. Deltamethrin (T,D) **.. 64. Dinocap (T,D) .. 67. Dodine (T,D) ** .. 68. _____. * New compound ** Evaluated within the periodic review programme of the Codex Committee on Pesticide Residues 1.

3 T, Toxicological evaluation; R, residue and analytical aspects; D, dietary risk assessment ii Fenitrothion (T, D) ** .. 72. Fenthion (R,D).. 77. Fipronil (T).. 78. Imazalil (T,D) ** .. 82. Malathion (R,D).. 86. Mevinphos (R).. 87. Parathion (R,D) ** .. 88. Parathion-methyl (R,D) **.. 97. Pyrethrins (R,D) **..107. Pyriproxyfen (R,D) ..116. Thiabendazole (R,D)..117. Thiodicarb (T,D).. 123. 5. Recommendations ..151. 6. Future work ..152. Annexes .. 133. Annex 1. Acute dietary intakes, acute reference doses, recommended maximum residue limits, and supervised trials median residue levels recorded by the 2000 Annex 2. Index of reports and evaluations of pesticides by the Joint Meeting Meeting on Pesticide Residues ..164. Annex 3. Dietary intakes of pesticides in relation to acute daily Annex 4.

4 Estimates of acute dietary intake ..189. Annex 5. Proposed test guidelines for studies with single oral doses (for use in establishing acute reference doses for chemical residues in food and drinking-water ..207. Annex 6. Reports and other documents resulting from previous Joint Meetings of the FAO Panel of Experts on Pesticide Residues and the environment and WHO Expert Groups on Pesticide Residues ..216. Annex 7. Corrections to the report of the 1999 Meeting ..221. iii List of participants 2000 Joint FAO/WHO Meeting on Pesticide Residues Geneva, 20 29 September 2000. WHO Members Professor Boobis, Section on Clinical Pharmacology, Division of Medicine, Imperial College School of Medicine, Hammersmith Campus, Ducane Road, London W12 0NN, United Kingdom Professor Borzelleca, Department of Pharmacology, Toxicology, Medical College of Virginia, Virginia Commonwealth University, (H) 8718 September Drive, Richmond, VA 23229-7319, USA.)

5 Dr P. Fenner-Crisp, Senior Science Advisor to the Director, Office of Pesticide Programs (7501C), US Environmental Protection Agency, 401 M Street SW, 20460 Washington DC, USA. Dr H. Hakansson, Institute of Environmental Medicine, Karolinska Institutet, Division of Risk Assessment and Organohalogen Pollutants, Box 210, 171 77 Stockholm, Sweden Professor J. Hajslova, Institute of Chemical Technology, Department of Food Chemistry and Analysis, Technick 3, 166 28 Prague 6, Czech Republic Dr A. Moretto, Department of Environmental Medicine and Public Health, Universit di Padova, via Giustiniani 2, 35128 Padova, Italy (Chairman). Professor Soliman, Department of Pesticide Chemistry, Faculty of Agriculture, Alexandria University, El-Shatby, Alexandria 21545, Egypt Dr Priestly, Scientific Director, Chemicals & Non-Prescription Medicines Branch, Therapeutic Goods Administration, Commonwealth Department of Health and Aged Care, PO Box 100, Woden, ACT 2606, Australia (Rapporteur).

6 FAO Members Dr Ursula Banasiak, Federal Biological Research Centre for Agriculture and Forestry, Stahnsdorfer Damm 81, 14532 Kleinmachnow, Germany Dr Susan May F. Calumpang, National Crop Protection Center, University of the Philippines, Los Ba os, Laguna, Philippines Dr Eloisa Dutra Caldas, University of Brasilia, College of Health Sciences, Pharmaceutical Sciences Department, Campus Universit rio Darci Ribeiro, 70919-970 Bras lia/DF, Brazil (Rapporteur). Dr Stephen Funk, Health Effects Division (7509C), US Environmental Protection Agency, 1200. Pennsylvania Ave NW, Washington DC 20460, USA. Mr Hamilton, Principal Scientific Officer, Animal & Plant Health Service, Floor 3 PIB, Department of Primary Industries, PO Box 46, Brisbane, Queensland 4001, Australia (Vice- Chairman).

7 Iv Mr Kazuo Ogura, Agricultural Chemicals Inspection Station, Suzuki-cyo 2-772, Kodairi-shi, Tokyo 187-0011, Japan Dr Bernadette C. Ossendorp, Centre for Substances and Risk Assessment, National Institute of Public Health and the Environment (RIVM), Antonie van Leewenhoeklaan 9, PO Box 1, 3720 BA. Bilthoven, The Netherlands Secretariat Dr Fernando Aguilar, International Programme on Chemical Safety, World Health Organization, 1211. Geneva 27, Switzerland Dr Dewhurst, Pesticides Safety Directorate, Mallard House, King's Pool, 3 Peasholme Green, York YO1 7PX, United Kingdom (WHO Temporary Adviser). Dr Dobozy, Health Effects Division (7509C), Office of Pesticide Programs, US Environmental Protection Agency, Ariel Rios Building, 1200 Pennsylvania Avenue NW, 20460 Washington DC, USA (WHO Temporary Adviser).

8 Dr van Eck, Chairman, Codex Committee on Pesticide Residues, Division of Public Health, Ministry of Health and Welfare and Sport, PO Box 20350, 2511 VX Den Haag, The Netherlands Dr J. van Engelen, Centre for Substances and Risk Assessment, National Institute of Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, PO Box 1, 3720 BA Bilthoven, The Netherlands (WHO Temporary Adviser). Dr John L. Herrman, International Programme on Chemical Safety, World Health Organization, 1211. Geneva 27, Switzerland (WHO Joint Secretary). Dr M. Hirose, Head, Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan (WHO Temporary Adviser). Dr Dugald MacLachlan, Chemistry & Residues Evaluation Section, National Registration Authority for Agricultural & Veterinary Chemicals, 22 Brisbane Avenue, PO Box E 240, Kingston, ACT.

9 2604, Australia (FAO Consultant). Dr Marrs, Food Standards Agency, Skipton House, 80 London Road, Elephant and Castle, London SE1 6LW, United Kingdom (WHO Temporary Adviser). Dr McGregor, 102 rue Duguesclin, 69006 Lyon, France (WHO Temporary Adviser). Dr Gerry Moy, Food Safety, World Health Organization, 1211 Geneva 27, Switzerland Dr Mueller, Chemicals & Non-Prescription Medicines Branch, Therapeutic Goods Administration, Commonwealth Department of Health and Aged Care, PO Box 100, Woden, ACT. 2606, Australia (WHO Temporary Adviser). Ms Barbara R stel, Chef d'unit Relations internationals, ANMV AFSSA, BP 90203, 35302. Foug res Cedex, France (FAO Consultant). Dr R. Solecki, Pesticides and Biocides Division, Federal Institute for Health Protection of Consumers and Veterinary Medicine, Thielallee 88-92, 14195 Berlin, Germany (WHO Temporary Adviser).

10 V Dr Tejada, Pesticide Management Group, Plant Protection Service, Plant Production and Protection Division, Food and Agriculture Organization of the United Nations, Viale delle Terme di Caracalla, 00100 Rome, Italy (FAO Joint Secretary). Dr Yukiko Yamada, Food Standards Officer, Joint FAO/WHO Standards Programme, Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Viale delle Terme di Caracalla, 00100 Rome, Italy Abbreviations vii Abbreviations (Well-known abbreviations in general use are not included). Ache acetylcholinesterase acute RfD acute reference dose ADI acceptable daily intake AFI(D) alkali flame-ionization (detector). ai active ingredient ALAT alanine aminotransferase AR applied radioactivity ASAT aspartate aminotransferase BBA Biologische Bundesanstalt f r Land- und Forstwirtschaft bw body weight BOD biological oxygen demand CA Chemical Abstracts CAS Chemical Abstracts Services CCN Codex Classification Number (this may refer to classification numbers for compounds or for commodities).