CONTENTS

1 3. CONTENTS . vii xix 1. 1. 2. GENERAL 3. Modifications to the agenda .. 3. Joint Meeting on 3. Toxicological criteria for estimating guidance values for dietary and non-dietary exposure to pesticides .. 5. Report of the Environmental Core Assessment group (Environmental CAG) .. 6. Data requirements for estimating ADIs and 7. Toxicological evaluation of pesticide exposure by the Core Assessment Group .. 7. Evaluation of pesticide residues by the FAO Panel .. 11. Assessment of acute dietary risk .. 12. Consultation on Application of Risk Analysis to Food Standards Issues - JMPR. response to specific 14. Residues .. 17. Definitions of pesticide residues .. 17. JMPR approach to estimating Extraneous Residue Limits (ERLs).. 21. MRLs at or about the limit of determination for multi-component 23. JMPR evaluations .. 26. Use of data by the 26. Use of JMPR Evaluations by regulatory authorities .. 27. Shortening JMPR reports on compounds - Section on residue and analytical 27.

2 Dietary intake of pesticide residues .. 30. Issues relevant to the establishment of guidelines for drinking-water quality .. 30. 3. SPECIFIC PROBLEMS .. 30. 4. EVALUATION OF DATA FOR ACCEPTABLE DAILY INTAKE FOR HUMANS. AND MAXIMUM RESIDUE LIMITS1 .. 31. Abamectin (T).. 31. Aldicarb (T)..32. Azinphos-methyl (R) .. 32. Benomyl (T,E)** .. 34. Bentazone (R) .. 40. Bifenthrin (R).. 41. 1. T = Toxicology * New compound R = Residue and analytical aspects ** Evaluation in periodic review programme E = Evaluation of effects on the environment 4. Buprofezin (R) .. 43. Captan (T) .. 52. Carbendazim (T,E)** .. 54. Cartap (T,R)**.. 57. Chlorpyrifos (R).. 58. Dithianon (R) .. 60. Dithiocarbamates (R).. 62. Ethephon (T) .. 62. Fenarimol (T,R,E)*.. 63. Fenpropimorph (R)*.. 77. Fenpyroximate (T,R)* .. 86. Fenthion (T,R,E)**.. 94. Flusilazole (T)..124. Folpet (T) ..127. Haloxyfop (T,R)* ..130. Iprodione (T)..143. Metalaxyl (R)..145. Metiram (R)*.

3 147. Monocrotophos (T)..156. Parathion (T,R)** ..156. Parathion-methyl (T)** ..162. Penconazole (R)..165. Piperonyl butoxide (T)** ..168. Profenofos (R)..172. Quintozene (T,R)**..173. Thiophanate-methyl (T,E)**..185. Triadimefon (R) ..189. Triadimenol (R) ..190. Vinclozolin (T) ..191. 5. 6. FUTURE WORK ..197. 1995 Meeting ..197. 1996 Meeting ..198. 7. REFERENCES ..199. CORRECTIONS TO REPORT OF 1994 ANNEX I ADIs and ANNEX II Index of reports and evaluations ..217. ANNEX III Intake predictions ..229. ANNEX IV Residues in 5. JOINT MEETING ON PESTICIDES. Geneva, 18-27 September 1995. PARTICIPANTS. Toxicological Core Assessment Group Dr Allan L. Black Medical Services Adviser in Toxicology Department of Human Services and Health GPO Box 9848. Canberra ACT 2601. Australia Tel: (61 6) 289 8464. Fax: (61 6) 289 6849. : Professor Joseph F. Borzelleca (Chairman). Pharmacology, Toxicology Medical College of Virginia Virginia Commonwealth University Box 613.

4 Richmond, VA 23298-0613. USA. Tel: (1 804) 828 8409 / 285 2004. Fax: (1 804) 285 1401. : Dr Penelope Fenner-Crisp (Rapporteur). Acting Deputy Director Office of Pesticide Programs (H7501C). US Environmental Protection Agency 401 M Street, Washington, 20460. USA. Tel: (1 703) 305 7092. Fax: (1 703) 308 4776. : 6 Participants Dr Angelo Moretto Istituto di Medicina del Lavoro Universit di Padova via Facciolati 71. 35127 Padova Italy Tel: (39 49) 82 16 644. Fax: same as telephone number Professor Olavi Pelkonen Professor of Pharmacology Department of Pharmacology and Toxicology University of Oulu Kajaanintie 52 D. FIN-90220 Oulu Finland Tel: (358 81) 537 5230. Fax: (358 81) 330 687. : Professor Andr Rico Biochemistry-Toxicology Physiopathology and Experimental Toxicology Laboratory (INRA). Ecole Nationale V t rinaire 23, ch. des Capelles 31076 Toulouse Cedex France Tel: (33 61) 310 142. Fax: (33 61) 193 978. Dr Peipei Yao Professor of Toxicology Consultant of ICAMA.

5 Institute of Occupational Medicine, CAPM. Ministry of Health 29 Nan Wei Road Beijing 100050. China Tel: (86 10) 301 6891 / 301 0863. Fax: (86 10) 301 4323 / 301 1875. E-mail: / Participants 7. Environmental Core Assessment Group Professor D. Calamari III Faculty of Sciences University of Milan via Ravasi 2. 21100 Varese Italy Tel: (39 332) 281 865. Fax: (39 332) 281 308. Dr S. Dobson (Vice-Chairman). Institute of Terrestrial Ecology Monks Wood Abbots Ripton Huntingdon Cambridgeshire PE17 2LS. UK. Tel: (44 1487) 773 381. Fax: (44 1487) 773 467. Dr Douben (Rapporteur). Pollution Inspector Her Majesty's Inspectorate of Pollution Room P3 018. 2 Marsham Street London SW1P 3EB. UK. Tel: (44 171) 276 5264. Fax: (44 171) 276 6544. : Dr J. Herkovits Director Programa Seguridad Quimica Instituto de Ciencias Ambientales y Salud (ICAS). Nicasio Oro o 710. 1405 Buenos Aires Argentina Tel: (541) 431 2445. Fax: (541) 431 4206. Dr Lise Sams e-Petersen VKI Water Quality Institute Agern All 11.

6 DK-2970 H rsholm Denmark Tel: (45) 4286 5211. Fax: (45) 4286 7273. : lsp@vki 8 Participants Dr Temmink Department of Toxicology, WAU. Box 8000. 6700 EA Wageningen The Netherlands Tel: (31 8370) 82656. Fax: (31 8370) 84931. : hanstemmink@ FAO Panel on Residues in Food and the Environment Dr A. Ambrus (Rapporteur). Budapest Plant Health and Soil Conservation Station Box 340. H-1519 Budapest Hungary Tel: (36 1) 1851 177 or 1851 110. Fax: (36 1) 1869 276 or 1869 737. Dr Ursula Banasiak Biologische Bundesanstalt Stahnsdorfer Damm 81. 14532 Kleinmachnow Germany Tel: (49 33203) 48338 / 22423. Fax: (49 33203) 22278. Mr S. Crossley Pesticides Chemistry Branch, Pesticide Safety Directorate Ministry of Agriculture, Fisheries and Food Mallard House Kings Pool 3 Peasholme Green York YO1 2PX. UK. Tel: (44 1904) 455 903. Fax: (44 1904) 455 711. Mr Hamilton Department of Primary Industries Meiers Road Indooroopilly Brisbane, Queensland 4068. Australia Tel: (61 7) 3896 9484.

7 Fax: (61 7) 3896 9623. Mr Ives (Vice-Chairman). Participants 9. Health Effects Division (H7509C). US Environmental Protection Agency 401 M Street, Washington, 20460. USA. Tel: (1 703) 305 6378. Fax: (1 703) 305 5147. Mrs E. Masoller Servicios de Laboratorios Ministerio de Ganaderia, Agricultura y Pesca Av. Millan 4703. Montevideo Uruguay Tel: (598 2) 393 181. Fax: (598 2) 396 508. Dr D. Murphy National Registration Authority Box 240. Queen Victoria Terrace Canberra ACT 2600. Australia Tel: (61 6) 272 3793. Fax: (61 6) 272 3551. Mr T. Sakamoto Assistant Director Plant Protection Division Ministry of Agriculture, Forestry and Fisheries 1-2-1 Kasumigaseki Chiyoda-ku 100 Tokyo Japan Tel: (813) 3501 3964. Fax: (81 3) 3591 6640. Secretariat Dr Elisabeth Bosshard Federal Office of Public Health Food Science Division Toxicology Section c/o Institute of Veterinary Pharmacology University of Z rich Winterthurerstrasse 260. 8057 Z rich Switzerland Tel: (41 1) 257 61 03.

8 10 Participants Fax: (41 1) 257 61 07. Dr Gary Burin Technology Sciences Group Suite 500. 1101 Seventeenth Street, Washington, 20036. USA. Tel: (1 202) 828 8980. Fax: (1 202) 872 0745. Dr Peter J. Campbell Pesticides Safety Directorate Ministry of Agriculture, Fisheries and Food Mallard House King's Pool 3 Peasholme Green York, YO1 2PX. UK. Tel: (44 1904) 455 910. Fax: (44 1904) 455 711. Mr David J. Clegg 142 Corkery Woods Drive Carp, Ontario K0A 1LO. Canada Tel: (1 613) 256 4518. Fax: same as telephone (call first). Dr van Eck Chairman Codex Committee on Pesticide Residues Food and Product Safety Division Ministry of Health, Welfare and Sport Postbox 3008. Sir Winston Churchillaan 362. 2280 MK Rijswijk The Netherlands Tel: (31 70) 340 69 66. Fax: (31 70) 340 5177. Dr Kannosuke Fujimori Division of Pharmacology Biological Safety Research Center National Institute of Health Sciences 18-1, Kamiyoga 1-chome Setagaya-ku Tokyo 158. Japan Tel: (81 3) 3700 1141.

9 Participants 11. Fax: (81 3) 3707 6950. Internet: Dr Rick Hailey Environmental Toxicology Program National Institute of Environmental Health Sciences Box 12233. Research Triangle Park, NC 27709. USA. Tel: (1 919) 541 0294. Fax: (1 919) 541 4714. : Dr John L. Herrman Assessment of Risk and Methodologies International Programme on Chemical Safety World Health Organization 1211 Geneva 27. Switzerland Tel: (41 22) 791 3569. Fax: (41 22) 791 48 48 / 791 0746. : Mrs Elisabeth Heseltine Communication in Science Lajarthe 24290 Saint-L on-sur-V z re France Tel: (33 53) 50 73 47. Fax: (33 53) 50 70 16. Mrs van Hoeven-Arentzen National Institute of Public Health and Environmental Protection Antonie van Leeuwenhoeklaan 9. Box 1. 3720 BA Bilthoven The Netherlands Tel: (31 30) 2743 263. Fax: (31 30) 2291 492. : Dr Kopisch-Obuch Pesticide and Weed Management Group Plant Protection Service Food and Agriculture Organization via delle Terme di Caracalla 00100 Rome Italy Tel: (39 6) 5797 5757.

10 12 Participants Fax: (39 6) 5797 3152. Dr Jens-J rgen Larsen Head, Department of General Toxicology Institute of Toxicology National Food Agency of Denmark Ministry of Health M rkh j Bygade 19. 2860 S borg Denmark Tel: (45 39) 69 66 00 ext 4100. Fax: (45 39) 66 01 00. : Dr Jan Linders National Institute of Public Health and Environmental Protection Box 1. 3720 BA Bilthoven The Netherlands Tel: (31 30) 2743 164. Fax: (31 30) 2291 492. : Dr Stephanie Ma Health Evaluation Division Pest Management Regulatory Agency Room 1005, 1st floor Main Statistics Building (0301B). Tunney's Pasture Ottawa, Ontario K1A OL2. Canada Tel: (1 613) 957 1681. Fax: (1 613) 941 2632. : Mr Antony F. Machin Boundary Corner 2 Ullathorne Road London SW16 1SN. UK. Tel: (44 181) 769 0435. Fax: same as telephone number Dr Douglas McGregor Unit of Carcinogen Identification and Evaluation International Agency for Research on Cancer 150 cours Albert-Thomas 69372 Lyon Cedex 08.