CURRICULUM VITAE Prof. GIORGIO WALTER …

1 CURRICULUM VITAE Prof. GIORGIO WALTER canonica Place of birth: Savona, Italy Date of birth: October 25th, 1947 Citizenship: Italian Home address: Via Lagustena 21/ 16131 Genova-ltaly Phone (010)3761058 Office Address: Allergy & Respiratory Diseases Department of Internal Medicine, Genoa University R. Benzi, 10- 16132 Genova - Italy Phone #39/10/3538933 Fax #39/10/3538904 E-mail TRAINING 1972 Medical Doctor-University of Genoa 1969/72 Department of Pulmonary Diseases, University of Genoa 1970 Department of Pulmonary Diseases (Dir. Prof. P. Sadoul), University of Nancy INSERM, France 1972 Specialist in Pulmonary Diseases University of Genoa 1977-97 Department of Internal Medicine, University of Genoa 1977 Department of Microbiology (Dir. Prof. Lorenzo Moretta), University of Genoa 1980 Department of Immunology (Dir. Prof. H. Wigzell), University of Uppsala, Sweden 1980 Specialist in Allergology and Clinical Immunology-University of Florence 1982 Department of Clinical Immunology (Prof.)

2 L. Moretta), Ludwig Institute for Cancer Research, Lausanne, Switzerland 1984/85 Department of Basic and Clinical Immunology ( ), Medical University of South Carolina, Charleston, ACADEMIC POSITIONS 1973 Assistant Professor Pulmonary Diseases Clinic University of Genoa 1977 Assistant Professor Dept. of Internal Medicine University of Genoa 1982 Associate Professor Allergy and Clinical Immunology-Dept. of Internal Medicine 1995 Full Professor of Allergy and Respiratory Diseases, Dept of Int Medicine, Genoa University 1997 Director of Specialty School of Allergy and Clin Immunology Dept of Int Med, Genoa University 1998 Chairman of the Allergy & Respiratory Diseases Clinic -Dept of Int Med, Genoa University 2001 Director of Specialty School of Pulmonary Diseases Genoa University MEMBERSHIP IN SOCIETIES P r e s i d e n t ( 2 0 0 7P r e s i d e n t ( 2 0 0 7--2 0 0 9 ) o f t h e W o r l d A l l e r g y O r g a n i z a t i o n2 0 0 9 ) o f t h e W o r l d A l l e r g y O r g a n i z a t i o n--WAOWAO P r e s i d e n t E l e c t ( 2 0 0 5P r e s i d e n t E l e c t ( 2 0 0 5--2 0 0 7 ) o f t h e W o r l d A l l e r g y O r g a n i z a t i o n2 0 0 7 )

3 O f t h e W o r l d A l l e r g y O r g a n i z a t i o n--WAOWAO V i c e P r e s i d e n t o f I N T E R A S M AV i c e P r e s i d e n t o f I N T E R A S M A-- I n t e r n a t i o n a l A s s o c i a t i o n o f A s t h m o l o g y I n t e r n a t i o n a l A s s o c i a t i o n o f A s t h m o l o g y S e c r e t a r y G e n e r a l o f t h e F e d e r a t i o n o f t h e I t a l i a n S e c r e t a r y G e n e r a l o f t h e F e d e r a t i o n o f t h e I t a l i a n M e d i c a l S o c i e t i e sM e d i c a l S o c i e t i e s--FISMFISM P r e s i d e n t ( 2 0 0 0P r e s i d e n t ( 2 0 0 0--2 0 0 3 ) o f S I M e R 2 0 0 3 ) o f S I M e R --I t a l i a n S o c i e t y o f R e s p i r a t o r y M e d i c i n eI t a l i a n S o c i e t y o f R e s p i r a t o r y M e d i c i n e V i c e P r e s i d e n t U I P ( I t a l i a n U n i o n f o r P u l m o n o l o g y ) F o u n d a t i o nV i c e P r e s i d e n t U I P ( I t a l i a n U n i o n f o r P u l m o n o l o g y ) F o u n d a t i o n Member of the EAACI-CME Continuing Medical Education Committee Secretary General of Italian Council for Accreditation in Pneumology - Continuing Medical Education (ICAP-CME) Member European Academy f Allergology and Clinical Immunology (EAACI) American Academy of Allergy, Asthma and Immunology, (AAAAI) until 2002 Fellow The American Association of Immunologists (AAI) The American College of Allergy,Asthma and Immunology (ACAAI) American College of Chest Physicians (ACCP) Fellow European Respiratory Society (ERS) Honorary Member.

4 Hungarian Allergy Society Rumanian Allergy Society Argentinian Allergy Society RESEARCH Main Topics: T Iymphocytes: investigation of different subsets and their functional role in basic and clinical research (Allergy, Organ specific autoimmunity, CNS degenerative diseases and cancer). Molecular events and Interactions between immunocompetent cells, inflammatory cells, epithelial cells in allergic inflammation and airways remodelling. New antiallergic drugs and new strategies in the allergic disease treatment. Clinical and immunopharmacological activities of Biological Responses Modifiers such as Cytokines, Monoclonal Antibodies,Allergen Specific Immunotherapy, Steroide etc. GWC served as referee for most of the mentioned journals . Editor in Chief of Current Opinion in Allergy and Clinical Immunology Editor of Annals of Allergy of ACII International the WAO journal EDUCATION 1966 Science Gymnasium O. Grassi, Savona 1972 School of Medicine, University of Genoa - Italy 1975 Specialist in Pulmonary Diseases, University of genoa 1975 Postgraduate course on "Allergologie et Immunologie Clinique", University of Marseille, France 1975/76 Lecturer, School of Specialization in Pulmonary Diseases, University of Genoa 1975/76 Lecturer, Postgradute Courses on Fiberbronchoscopy and Respiratory Allergy, University of Genoa 1977/83 National Research Council (CNR) - Researcher.

5 Program on "Controllo della Crescita Neoplastca" - Basic Immunology 1979 First Intensive Course Basic Immunology, by European Molecolar Biology Organization, University of Pavia 1981 Specialist in Allergy and Clinical Immunology, University of Florence AWARDS 1971/73 Recognition of Outstanding Scientific Achievement, University of Genoa 1980 European Molecular Biology Organization (EMBO) Fellowship 1980 International Union Against Cancer (UICC) Fellowhip 1980 Special Award from Italian National Research Council (CNR) 1982 Award from It Society f Ophtalmology and Merck Sharp & Dome for studies on Allergy Pubblicazioni Internazionali Prof. canonica 1. Valenti S., canonica Biopsies en pneumologie: pleuroscopie-biopsies. Le Poumon et le Coeur. 6: 357-361 1975 2. Moretta L., Mingari , Moretta A., canonica , Cooper Subpopulation of human T lymphocytes, functional characteristics.

6 In B lymphocyte activation in humans. Fauci & Ballieux Eds. Academic Press 379-388 1978 3. canonica , Mingari , Melioli G., Colombatti M., Moretta L. Imbalance of T cells subpopulations in patients with atopic diseases and effect of specific immunotherapy. Journal of Immunology 123: 2669-672 1979 4. Mingari , Moretta A., canonica , Colombatti M., Moretta L. Immunoregulatory T cell subpopulations in man. In Lymphocyte Stimulation: sensitivity to radiation. Biochemical and immunological processes. Castellani A. Ed. Plenum Publishing Corp. New York 161-166 1980 5. Moretta A., Mingari , canonica , Colombatti M., Moretta L. Fc-receptors on human T Iymphocytes: relationship with cell functions and modifications under certain in vitro conditions. In Thymus, Thymic Hormones and T Iymphocytes Aiuti F. & Wigzell H. Eds. Academic Press 31-38 1980 6. canonica , Pistoia V.

7 , Ghio R., Mingari , Moretta L. Suppressor activity of T cells bearing Fc-receptors for IgG on lymphoid colony formation. Scandinavian Journal of Immunology 12: 507-511 1980 7. Moretta L., Bacigalupo A., Moretta A., canonica , Mingari Human T cell subpopulations: detection of suppressor activity in several in vitro and in vivo conditions. "Suppressor Cells in Humans" (Serrou B., Rosenfeld C. Eds) North Holland Publ. 65-90, 1981 8. canonica G. W., Bagnasco M., Moretta L., Cocco R., Ferrini O., Giordano G. Human T Iymphocyte subpopulation in Hashimoto's diseases. J. Clin. Endocrinol. Metab. 52: 553-556, 1981 9. Ferrini S., Bagnasco M., Ramarli D., Melioli G., canonica Hashimoto's thyroiditis: influence of adherent cells on T Iymphocytes colony growth. IRCS Med. Sci. 9: 1085-86, 1981 10. Moretta L., Moretta A., canonica , Bacigalupo A., Mingari , Cerottini Receptors for immunoglobulins on resting and activated human T cells.

8 Immunological Review 56: 141-162, 1981 11. Mingari , Moretta A., canonica , Melioli G., Corte G., Moretta L. Definition of human T cell subpopulations by the use of surface markers: new strategies. In Update on Medicine Casciani Ed. 1981 12. Pistoia V., Ghio R., canonica , Colombatti M., Moretta L. Comparison of the colony forming capacities of human T Iymphocyte subpopulations. Clinical Immunology and Immunopat. 21: 289-294, 1981 13. De Simone C., canonica , Corte G., Meli D. Influence of Methisoprinol on surface antigens of T Iymphocytes. Current Chemiotherapy & Immunotherapy 1161-62, 1981 14. Bagnasco M., Ferrini S., Schenone F., Machi , canonica , Melioli G. A microplate Enzyme Immunoassay for the detection of anti-thyroglobulin autoantibodies IRCS Med. Sci. 10: 21-22, 1982 15. canonica , Bagnasco M., Corte G., Ferrini S., Ferrini O., Giordano G.

9 Circulating T lymphocytes in Hashimoto's disease: imbalance of subsets and presence of activated cells Clin. Immunol. Immunopathol. 23: 616-625, 1982 16. Mingari , Moretta A., canonica , Melioli G., Corte G., Moretta L. Changes of the Fc receptor phenotype on human T Iymphocytes: consequences on the helper and suppressor activities of the Pokeweed mitogen-driven B cell differentiation. In Human B cell activation Fauci Ed. Raven Press 195-200, 1982 17. Ramarli D., canonica , Melioli G., Biagioni P., Nieri S., Casini A., Surrenti C. Abnormalities of immunocompetent cells in primary biliary cirrhosis. Scandinavian Journal of Immunology 16: 201-207, 1982 18. canonica , Kabelitz D., Sjoberg O., Aigrain Y., Wigzell H. Density distribution profiles of T cells: T, T , T , cells and response patterns in autologous versus allogenic MLRs. Scandinavian Journal of Immunology 16: 243-248, 1982 19. Melioli G.

10 , De Micheli A., Prando R., Maiello M., Raffanti S., Mach , canonica Lack of evidence of anti-insulin IgE tested by PRAST in insulin allergy. 10: 9-9, 1982 20. Kabelitz D., canonica , Sjoberg O., Klareskog L., Wigzell H. Inhibition of autologous mixed lymphocyte reaction by aggregated IgG molecules. European Journal of Immunology 12: 687-691, 1982 21. Bagnasco M., canonica , Ferrini S., Biassoni P., Melioli G., Ferrini O., Giordano G., T lymphocyte subpopulation in Graves' disease: relationship with clinical conditions Acta Endocrinol. 102: 213-219, 1983 22. Bagnasco M., canonica , Ferrini S., Ciprandi G., Dirienzo W., Giordano G., Ferrini O. Circulating T-cells subsets in euthyroid Graves' disease J. Endocrinol. Invest. 6: 119-123, 1983 23. canonica , Bagnasco M., Ferrini S., Biassoni P., Giordano G., Corte G. Circulating T-cells subsects in Graves' disease: differences between patients with active disease and in remission after 131-I therapy.