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ICH-M7ガイドラインの概要と今後の ... - NIHS

Bas e + toluene Pd c a tlys / Ligand 1) con H 2SO4 LiOt-Bu THF 1) NaBH4 /O Mg Cl2 /MeOH F3C X C N NH2 F 3 C H CN F C N H O NH2 F3C N H O N H O O 2) aqHCl F 3 C N HN O O F 3 C N HN O O O O Sodium carbonate Tetrahydrofuran

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