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Infectious viral load in unvaccinated and vaccinated ...
Jan 10, 2022 · 67 Although the process of human-to-human transmission is complex, VL can serve as a proxy, with 68 higher VL posing a greater risk for onward transmission. In several epidemiological studies, higher viral 69 load expressed as viral RNA was associated with an increased secondary transmission in household 70 settings(3, 4).
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It is made available under a CC-BY-NC-ND 4.0 International ...
www.medrxiv.orgDec 02, 2021 · (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. 0 It is made available under a CC-BY-NC-ND 4.0 International license .
Comparison of infectious SARS-CoV-2 from the nasopharynx ...
www.medrxiv.orgDec 28, 2021 · asymptomatic score) (Figure 1C). Collectively, these observations suggest that SARS-CoV-2 vaccines may not alter the levels of replicating virus in the upper respiratory tract once viral infection establishes but may instead protect through accelerated clearance or enhanced neutralization of infectious viral particles [6].
It is made available under a CC-BY-NC-ND 4.0 International ...
www.medrxiv.orgJul 28, 2021 · immunization follow-up from a global phase 1/2/3 trial of BNT162b2 in ≥16-year-olds. Vaccine efficacy (VE) against COVID-19 was 95%. BNT162b2 had a favorable safety profile in diverse populations.9 These data formed the basis …
2021.12.14 Bolton H3N2Glycan - medrxiv.org
www.medrxiv.orgDec 15, 2021 · 160 glycan in shaping the binding specificity of the new 2a2 H3N2 HAs for sialoside receptors. The types and prevalence of different sialo-linked receptors in the human respiratory tract is incompletely understood, and therefore it is difficult to interpret how changes in sialoside glycan specificity may affect viral fitness.
Omicron outbreak at a private gathering in the Faroe ...
www.medrxiv.orgDec 22, 2021 · Title: Omicron outbreak at a private gathering in the Faroe Islands, infecting 21 of 33 triple-vaccinated healthcare workers Author: Administrator
Saliva swabs are the preferred sample for Omicron detection
www.medrxiv.orgDec 22, 2021 · 10 3Green Point Diagnostic Virology Laboratory, National Health Laboratory Service, 11 Cape Town, South Africa 12 13 *Corresponding author 14 Email: [email protected] 15 16 It is made available under a CC …
Omicron infection enhances neutralizing immunity against ...
www.medrxiv.orgDec 27, 2021 · Pooled samples were quantified using Qubit 3.0 or 4.0 125 fluorometer (Invitrogen Inc.) using the Qubit dsDNA High Sensitivity assay according to manufacturer’s 126 instructions. The fragment sizes were analyzed using TapeStation 4200 (Invitrogen). The pooled 127 libraries were further normalized to 4nM concentration and 25 μL of each ...
Analytical sensitivity of seven SARS-CoV-2 antigen ...
www.medrxiv.orgDec 18, 2021 · 35 potential impact on diagnostic performance. SARS-CoV-2 antigen-detecting rapid diagnostic 36 tests (Ag-RDT) offer quick, cheap and laboratory-independent results at the point of care.1 37 Although sensitivity is lower compared to RT-PCR, they enable reliable detection of high viral
Comparison of outcomes from COVID infection in pediatric ...
www.medrxiv.orgDec 30, 2021 · CoV-2 infection. Based on CDC data, Delta was the predominant variant at that time (98.6-99.1%)1; (c) the Delta-2 cohort (n = 77,692) – patients who had their first SARS-CoV-2 infections between 11/16/2021–11/30/2021, immediately before the Omicron variant was detected in the US, and had no prior SARS-CoV-2 infection.
Protection afforded by prior infection against SARS-CoV-2 ...
www.medrxiv.orgJan 05, 2022 · exact matched in a ratio of one-to-five by sex, 10-year age group, nationality, and calendar week of the PCR test (Figure 1 and Table 1). Infection with Alpha, Beta, or Delta variants was ascertained using real-time reverse-transcription PCR (RT-qPCR) genotyping of the positive clinical samples 11,12(Section S1).
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