SIDS Initial Assessment Report For SIAM 22 TOME …

1 OECD sids LONG CHAIN ALCOHOLS. sids Initial Assessment Report For siam 22. Paris, France, 18 21 April 2006. TOME 1: SIAR. Category Name Long Chain Alcohols (C6-22 primary aliphatic alcohols). 1. and 2. Chemical CAS no. Chemical name Names and CAS numbers 111-27-3 1-Hexanol 111-87-5 1-Octanol 112-30-1 1-Decanol 112-42-5 1-Undecanol 112-70-9 1-Tridecanol 112-72-1 1-Tetradecanol 629-76-5 1-Pentadecanol 36653-82-4 1-Hexadecanol 143-28-2 9-Octadecen-1-ol, (9Z)- 629-96-9 1-Eicosanol 661-19-8 1-Docosanol 63393-82-8 Alcohols, C12-15. 66455-17-2 Alcohols, C9-11. 67762-25-8 Alcohols, C12-18.

2 67762-27-0 Alcohols, C16-18. 67762-30-5 Alcohols, C14-18. 67762-41-8 Alcohols, C10-16. 68551-07-5 Alcohols, C8-18. 68002-94-8 Alcohols, C16-18 and C18 Unsaturated 68155-00-0 Alcohols, C14-18 and C16-18-unsatd. 68333-80-2 Alcohols, C14-16. 68603-15-6 Alcohols, C6-12. 68855-56-1 Alcohols, C12-16. 75782-86-4 Alcohols, C12-13. 75782-87-5 Alcohols, C14-15. 80206-82-2 Alcohols, C12-14. 85566-12-7 Alcohols, C8-10. 85665-26-5 Alcohols, C10-12. 97552-91-5 Alcohols, C18-22. 90583-91-8 Tridecanol, branched and linear 3. Sponsor Country: United Kingdom 1. OECD sids LONG CHAIN ALCOHOLS. 4.

3 Shared Partnership with: 5. Roles/Responsibilities of the Partners: Name of industry sponsor Global ICCA Aliphatic Alcohols Consortium /consortium Process used The robust summaries were prepared by contractors to the Global ICCA Aliphatic Alcohols Consortium (GIAAC). The data matrix, SIAR and IUCLID dossiers were prepared by Shell Chemicals Ltd and a contractor, Peter Fisk Associates. 6. Sponsorship History How was the chemical or category brought into the OECD HPV Chemicals Programme ? 7. Review Process Prior to All information was reviewed by the Global ICCA Aliphatic the siam : Alcohols Consortium.

4 UK government (the Environment Agency of England and Wales, and MRC Institute for Environment and Health) peer-reviewed the sids documents, and audited selected key studies to check the robust study summaries. 8. Quality check process: 9. Date of Submission: 10. Date of last Update: 11. Comments: sids dossiers already existed for 1-Dodecanol (CAS 112-53-8). and 1-Octadecanol (CAS 112-92-5) (published in 1998 and 1995. respectively); the present document updates and extends the earlier ones; brings in new information, and therefore replaces it. No conclusions drawn in the earlier review are amended.

5 Available data for these substances are compiled in sids . dossiers related to each CAS number. The reliability of each data point has been considered during this period of review, in accordance with the guidance of the Fraunhofer Institut f r Toxikologie und Aerosolforschung. The following standard reliability codes, defined by Klimisch et al. (1997)1, apply, in accordance with the sids guidance: (1) Valid without restriction (2) Valid with restrictions (3) Invalid (4) Not assignable. Results considered to be Invalid are not used in the discussions or conclusions in this Report .

6 However, results which are of Non-assignable reliability may be fully valid, although 1 Klimisch, HJ, Andreae, E and Tillmann, U 1997. A systematic approach for evaluating the quality of experimental and ecotoxicological data. and Pharm. 25:1-5. 2. OECD sids LONG CHAIN ALCOHOLS. insufficient details were available to be sure of this; therefore reliability (4) results are used in this Report . The reliability code of each data point is given. Key studies are flagged in the sids dossiers. These are studies with the highest reliability/adequacy. If several studies showed comparable reliability/ adequacy, the study with the lowest LC/LD/EC50 or NOEC/ NOAEL has been indicated as the key study.

7 For some endpoints, fully reliable results are not available and it has been necessary to use a weight of evidence including results of studies of non-assignable reliability. In such cases the results are identified as key studies as they are of high importance to the data set. For transparency, some study summaries in the sids dossier have been transferred from the previously published version of IUCLID or from the previous sids submission. In some cases, it has not been possible to retrieve the original literature/study reports using the reported citation or as a result of literature searching.

8 In some cases, change of business ownership meant that internal study reports cited in previous summaries could not be accessed. In some other cases, certain non- sids . endpoints, and in areas where a very large amount of literature has been published, it was not considered necessary to pursue all individual published sources due to weight of evidence of more reliable results. In all cases, reliability (4) applies, because the original documentation has not been reviewed in the development of the dossier. Such results are clearly identified in the sids dossier and more details are given therein.

9 3. OECD sids LONG CHAIN ALCOHOLS. sids Initial Assessment PROFILE. Chemical Category Name Long Chain Alcohols (C6-22 primary aliphatic alcohols). Chemical name CAS no. Chemical name CAS no. 1-Hexanol 111-27-3 Alcohols, C16-18 67762-27-0. 1-Octanol 111-87-5 Alcohols, C14-18 67762-30-5. 1-Decanol 112-30-1 Alcohols, C10-16 67762-41-8. 1-Undecanol 112-42-5 Alcohols, C8-18 68551-07-5. 1-Tridecanol 112-70-9 Alcohols, C14-16 68333-80-2. 1-Tetradecanol 112-72-1 Alcohols, C6-12 68603-15-6. 1-Pentadecanol 629-76-5 Alcohols, C12-16 68855-56-1. 1-Hexadecanol 36653-82-4 Alcohols, C12-13 75782-86-4.

10 CAS Nos 1-Eicosanol 629-96-9 Alcohols, C14-15 75782-87-5. 1-Docosanol 661-19-8 Alcohols, C12-14 80206-82-2. Alcohols, C12-15 63393-82-8 Alcohols, C8-10 85566-12-7. Alcohols, C9-11 66455-17-2 Alcohols, C10-12 85665-26-5. Alcohols, C12-18 67762-25-8 Alcohols, C18-22 97552-91-5. 9-Octadecen-1-ol 143-28-2 Alcohols, C14-18. 68155-00-0. (9Z)- & C16-18-unsatd Alcohols, C16-18 68002-94-8 Tridecanol, 90583-91-8. & C18 Unsaturated branched & linear Structural Formula CH3(CH2)nCH2OH Linear n = 4 to 20. CH3(CH2)nCHCH2OH 2-Alkyl branched n + m = 3 to 18, and m is (CH2)mCH3 predominantly = 0.