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Thermo Scientific Crosslinking Technical Handbook
Carboxylic acid-reactive chemical groups Carboxylic acids (–COOH) exist at the C-terminus of each polypeptide chain and in the side chains of aspartic acid (Asp, D) and glutamic acid (Glu, E). Like primary amines, carboxyls are usually on the surface of protein structure. Carboxylic acids are reactive towards carboiimides.
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