This document is intended for internal use only …

1 This document is intended for internal use only and shall not be distributed outside of Boston Order Title Description1 Animation: Advanix Biliary Stent with NaviFlex RX Delivery SystemAnimation. Advanix Biliary Stent with NaviFlex RX Delivery System. This animation demonstrates the general deployment procedure for the Advanix biliary stent system. 2 Animation: Biliary access cannulation techniquesThis animation demonstrates various biliary access cannulation techniques and the clinical benefits of each. Techniques include wire guided cannulation, catheter access and catheter engagement cannulation techniques. 3 Perspectives on wire-guided cannulation, Prof. Marco BrunoPhysician perspective on short wire systems and wire guided cannulation: techniques, benefits, tips and tricks. Prof. Marco Bruno.

2 4 Case Study Deployment of bi-lateral WallFlex Biliary RX Stents, Thomas Kowalski, MD In-Depth Case Study. Deployment of bi-lateral WallFlex Biliary Metal Stents, presented by Dr. Thomas Kowalski of Thomas Jefferson University Hospital, Philadelphia, PA - takes you step by step through the deployment procedure for placing bi-lateral WallFlex Stents for biliary decompression. 5 Animation. WallFlex Fully Covered Biliary Metal Stent animation with clinical footageWallFlex Fully Covered Biliary Metal Stent animation. This animation includes clinical footage and demonstrates the features of this stent as well as the deployment procedure. Footage courtesy of Dr. Thomas Kowalski. 6 Case Study. Deployment of a WallFlex Duodenal Stent, presented by Dr. Irving WaxmanCase study.

3 Deployment of a WallFlex Duodenal Stent, presented by Dr. Irving Waxman, University of Chicago, Pritzker School of Medicine, Chicago, IL. 7Q&A with MDs. When to Stent vs Surgery, Irving Waxman, MD (GI) & Kevin Roggin, MD (Surgeon)Q&A with physicians. When to Stent vs Surgery - with Dr. Irving Waxman (GI) and Dr. Kevin Roggin (Surgeon), University of Chicago, Pritzker School of Medicine, Chicago, IL. 8Q&A with MDs. Patient Selection for Duodenal Stents, Irving Waxman, MD & Kevin Roggin, MDQ&A with physicians. Patient Selection for Duodenal Stents, with Waxman (GI) and Dr. Kevin Roggin (Surgeon), University of Chicago, Pritzker School of Medicine, Chicago, IL. This document is intended for internal use only and shall not be distributed outside of Boston study. Large stone therapy using Holmium Laser with SpyGlass System, Sandeep Patel, DO Case study on ERCP stone therapy using holmium laser lithotripsy with the SpyGlass System, presented by Sandeep Patel, DO, Christus Santa Rosa Health System, San Antonio, Texas.

4 10 Case Study. Large stone therapy using EHL with SpyGlass System, D. Pleskow, MDCase Study. A procedural case study on large stone management using the SpyGlass System with electrohydraulic lithotripsy (EHL) in the bile duct, presented by Douglas Pleskow, MD, Beth Israel Deaconess Medical Center, Boston, MA. 11 Case Study. Tissue Acquisition using the SpyGlass System, D. Adler, MDCase study, Douglas Adler, MD, University of Utah School of Medicine, Salt Lake City, Utah, from the August 2009 live webcast on Large Stone Management (EHL) and Tissue Acquisition Using the SpyGlass Direct Visualization System. 12 Presentation, Part 1 of 2, Pancreatoscopy with SpyGlass System, Pete Stevens, MDPart 1 of 2 - Presentation given by Peter D. Stevens, MD, Columbia University, New York Presbyterian Hospital, New York, New York, on Practical Pancreatoscopy using the SpyGlass Direct Visualization System from the July 2010 SpyGlass System live webcast.

5 13 Presentation. Part 2 of 2, Pancreatoscopy with SpyGlass System, Pete Stevens, MDPart 2 of 2 - Presentation given by Peter D. Stevens, MD, Columbia University, New York Presbyterian Hospital, New York, New York, on Practical Pancreatoscopy using the SpyGlass Direct Visualization System, July 2010 SpyGlass System live webcast. 14Q&A from Webcast. What is your experience acquiring tissue in the pancreas using SpyGlass System?Q&A from the July 2010 live webcast on Therapeutic Cholangio-Pancreatoscopy using the SpyGlass Direct Visualization System, Pete Stevens, MD, Columbia University, New York Presbyterian Hospital, New York, New York. 15Q&A from Webcast. Are there concerns using the SpyGlass System in the pancreas?Q&A from the July 2010 live Webcast on Therapeutic Cholangio-Pancreatoscopy using the SpyGlass Direct Visualization System, featuring Peter D.

6 Stevens, MD, Columbia University, New York Presbyterian Hospital, New York, New York. 16 Presentation from Webcast. SpyGlass System tissue acquisition clinical registry data, D. Adler, MDPresentation, Douglas Adler, MD, University of Utah School of Medicine, Salt Lake City, Utah, from the August 2009 live Webcast on Tissue Acquisition using the SpyGlass Direct Visualization System. This document is intended for internal use only and shall not be distributed outside of Boston of SpyGlass System clinical registry data for stone management, Douglas Pleskow, MDPresentation by Douglas Pleskow, MD, Beth Insrael Deaconess Medical Center, Boston, Mass., from the August 2009 live webcast on Large Stone Management and Tissue Acquisition Using the SpyGlass Direct Visualization System. 18Q&A from Webcast. How do you control fluid from irrigation during SpyGlass System procedures?

7 Douglas Pleskow, MD, Beth Israel Deaconess Medical Center, Boston, Massachusetts, and Douglas Adler, MD, University of Utah School of Medicine, Salt Lake City, Utah, answer questions after a live webcast on the SpyGlass Direct Visualization System, June 2009. 19Q&A from Webcast. Why would you set up the SpyGlass System for every case? Douglas Pleskow, MD, Beth Israel Deaconess Medical Center, Boston, Massachusetts, and Douglas Adler, MD University of Utah School of Medicine, Salt Lake City, Utah, answer questions after a live Webcast on the SpyGlass Direct Visualization System, June 2009. 20 Intraductal Footage. Direct visualization of biliary & pancreatic ducts using the SpyGlass System SpyGlass System intraductal footage - direct visualization of the biliary and pancreatic ducts using the SpyGlass System.

8 See the intrahepatic ducts, strictures and stones. 21 Intraductal Footage of Tissue Acquisition in the biliary & pancreatic ducts using SpyGlass SystemIntraductal footage of tissue acquisition in the biliary and pancreatic ducts using the SpyBite forceps with the SpyGlass Direct Visualization System. See optically-guided biopsies of biliary strictures and IPMN strictures in the pancreas. 22 Intraductal footage using Holmium Laser with the SpyGlass System for large stones in the CBD Intraductal footage shows use of a Holmium Laser fiber with the SpyGlass Direct Visualization System to manage large stones in the bile duct. 23 Intraductal footage using EHL with SpyGlass System for large stones in the bile duct Intraductal footage shows treatment of large stones in the bile duct using an EHL fiber with the SpyGlass Direct Visualization System.

9 ERCP (continued)This document is intended for internal use only and shall not be distributed outside of Boston ManagementPlaylist Order Title Description1 WallFlex Partially Covered Esophageal Stent Placement - Patient Video A Patient Story - See how the WallFlex Esophageal Stent, thanks to Dr. David Carr-Locke from Brigham & Women s Hospital in Boston, MA, enabled a patient with esophageal cancer to eat again. 2 WallFlex Fully Covered Esophageal Stent Placement - Patient Video Hear how a multidisciplinary approach to esophageal cancer is critical when treating a patient with esophageal cancer. See how the WallFlex Fully Covered Esophageal Stent, thanks to Bizekis, a cardiothoracic surgeon from NYU School of Medicine, enabled a patient with esophageal cancer to eat again and keep food down.

10 3 Balloon Endoscopy with the CRE Balloon DilatorThis animation and short video clip shows how balloon endoscopy with the CRE Balloon is used to dilate strictures of the GI Esophageal Stent case studies and procedural footage - Dr. Ed Schafer Procedural Footage and case study from Dr. Ed Schafer from Nebraska Medical Center featuring the placement of a WallFlex Partially Covered Esophageal Stent for a recurrent tumor of the distal esophagus. 5 WallFlex Partially Covered Esophageal Stent Placement - Dr. MeckstrothProcedural Footage from Dr. Steven A. Meckstroth from North Naples Hospital in Naples, Florida featuring the placement of a WallFlex Partially Covered Esophageal Stent for dysphagia and partial obstruction of the indwelling stent with overgrowth of the stent distally at the gastric cardia.