Transcription of UNDERSTANDING MSI-H/dMMR - Merck.com
1 UNDERSTANDING . MSI-H/dMMR . A guide FOR PATIENTS, CAREGIVERS AND ADVOCATES. Our UNDERSTANDING of cancer is always growing. Recently, scientists uncovered new uses for biomarkers called MicroSatellite Instability High (MSI-H) or MisMatch Repair deficiency (dMMR). These biomarkers can be found in many different types of cancers. Learn more about MSI-H/dMMR below and remember to ask your doctor if biomarker testing is right for you or your loved one. WHAT IS A BIOMARKER? IS MSI-H/dMMR ASSOCIATED WITH A SPECIFIC. Biomarkers may be used to better understand some of the TYPE OF CANCER? characteristics of your cancer. Getting tested for biomarkers MSI-H has been found in many different types of cancer. helps your doctor decide what options are right for you.
2 WHO SHOULD BE TESTED FOR MSI-H? WHAT IS MSI-H/dMMR ? Patients should talk to their doctors to see if MSI-H/dMMR testing MSI-H is short for High levels of MicroSatellite Instability. is appropriate. dMMR stands for deficient MisMatch Repair. MSI-H/dMMR can occur when a cell is unable to repair mistakes made during the division process. HOW DO YOU TEST FOR MSI-H/dMMR ? Doctors use two types of tests to determine if MSI-H/dMMR . WHAT CAUSES MSI-H/dMMR ? biomarkers are present: Normal cells have a system that sees and repairs mistakes that Immunohistochemical staining (IHC) uses the tumor tissue happen when the DNA is copied. It's called the mismatch repair from the biopsy system. Sometimes the system stops working properly.
3 When this happens, errors in the DNA start accumulating and may cause Polymerase chain reaction (PCR) tests compare tumor cancer. MSI-H/dMMR can be hereditary or random. tissue from the biopsy to a normal tissue to measure microsatellite instability Both methods are tests readily available in the So, ask your doctor about biomarker testing, for MSI-H/dMMR . specifically, today.
