WHO Drug Dictionary

1 Magnus WallbergDar Es Salaam, TanzaniaNovember drug DictionaryMagnus Wallberg, UMCA dalatBamylBroadcillinPeniclineAcetylsali cylic acidAmpicillinNifedicorAlvedonMagnecylPa nodolNifedipineAspirinPanodilViccilinPar acetamolAmpicillin sodiumMagnus Wallberg, UMCA dalat Bamyl Broadcillin Penicline Acetylsalicylic acidAmpicillinNifedicor Alvedon Magnecyl Panodol NifedipineAspirin Panodil Viccilin ParacetamolAmpicillin sodiumMagnus Wallberg, UMCG eneral information The WHO drug Dictionary contains data from 1968 onwards The content today is originating mostly from IMS and National drug names References No entries are deleted even though they are withdrawn from the market, since old case reports might be coded with these products. They are marked as OLD FORMDrug/Medicinal Product Classification Structure to allow easy and flexible data retrieval and analysis Classifications Chemical Indication Hierarchical to allow different levels of precision to facilitate navigation and aggregation Up to dateMagnus Wallberg, UMCThe WHO drug Dictionary (WHO-DD)

2 A database with information about medicinal products from all over the world it contains medicinal products and information related to them in a relational database system Information is provided in a consistent and structured way It provides useful groupings of data useful for both data input and output It is continuously updatedMagnus Wallberg, UMCThe WHO-DD A source of international drug names Substance names according to International Non Proprietary Names (INN) Drugs classified according to the Anatomical-Therapeutic-Chemical (ATC) classifications system Information on companies and reference sourcesMagnus Wallberg, UMCM agnus Wallberg, UMCM edicinal product names Proprietary names single-ingredient multiple-ingredient Nonproprietary/Generic names single-ingredient multiple-ingredientPreferred name Single ingredient drugs Nonproprietary names Multiple ingredient drugs Trade names First reported brand of a given ingredient combination Nonproprietary namesMagnus Wallberg, UMCT ypes of medicinal products in WHO-DD The majority of the entries refer to conventional (chemical substance)

3 Medicinal products but the WHO-DD also includes herbal remedies vaccine blood products homeopatic remedy dietary supplementMagnus Wallberg, UMCM agnus Wallberg, UMCC odes and IDs Link products with the same ingredients generics brands Link products containing the same base ingredient, but different salt/estersParticularly important for international exchange of information, since there are different product names in different countriesMagnus Wallberg, UMCC odes and IDs drug Code identifies Ingredient(s) Salts/Esters Names Medicinal Product ID identifies a unique entry a numeric 000027 01 004 Magnecyl 000027 01 006 Magnus Wallberg, UMCHow do we use WHO-DD Those who report ICSRs to the UMC need to give the product name and when needed the National product name compendia The reported medicinal product is linked to the WHO-DD which contains more information on the productICSRP atient dataReaction dataMedication dataVioxx 5 mg dMore 5 mg tabletMerck, SwedenATC code: M01 AHIngr.

4 : rofecoxibWHO-DDVigiBase ICSR databaseMagnus Wallberg, UMCWith the WHO-DD linked to ICSRs we can Sort Group SearchICSRs according to: product name ingredients therapeutic group exampleIngredient/BaseSalt/EsterBrand nameMedicinal productParacetamol-Alvedon500 mg TabletsParacetamol-AlvedonFluidParacetam ol-AcetamolTabletsParacetamolParacetamol sodiumAcetasodIntravenousParacetamolPara cetamol hydroclorideAceclorideUnspecifiedMagnus Wallberg, UMC12341 Search on medicinal product level2 Search on brand name level3 Search on Salt/Ester level4 Search on base ingredient levelMagnus Wallberg, UMCATC in WHO drug DictionaryATC Classification Index issued by the WHO Collaborating Centre, Oslo, NorwayMagnus Wallberg, UMCATC in WHO drug Dictionary Help for drug utilisation research Hierarchical classification useful for navigation and aggregation Applicable to both single and multiple ingredient drugs Medicinal products are classified according to the main therapeutic use Revised yearlyMagnus Wallberg, UMCATC in WHO drug DictionaryMedicineChemical drugCNS drugSedativeBenzodiazepineDiazepamValium Valium tabletValium 10mg tabletReport entryATCA natomical levelTherapeutic levelChemical levelGeneric level (ingredient/s)

5 Proprietary name levelN05BA - Benzodiazepine derivativesMagnus Wallberg, UMCATC Classification Main GroupsScreen shot from DD BrowserMagnus Wallberg, UMCS creen shot from DD BrowserAn exampleIngredient/BaseSalt/EsterBrand nameMedicinal productParacetamol-Alvedon500 mg TabletsParacetamol-AlvedonFluidParacetam ol-AcetamolTabletsParacetamolParacetamol sodiumAcetasodIntravenousParacetamolPara cetamol hydroclorideAceclorideUnspecifiedMagnus Wallberg, UMC12341 Search on medicinal product level2 Search on brand name level3 Search on Salt/Ester level4 Search on base ingredient levelAn exampleIngredient/BaseSalt/EsterBrand nameMedicinal productParacetamol-Alvedon500 mg TabletsParacetamol-AlvedonFluidParacetam ol-AcetamolTabletsParacetamolParacetamol sodiumAcetasodIntravenousParacetamolPara cetamol hydroclorideAceclorideUnspecifiedAcetyls alicylic acid-AspirinTabletsMagnus Wallberg, UMCAn exampleATC codeIngredient/BaseSalt/EsterBrand nameMedicinal productN02 BEParacetamol-Alvedon500 mg TabletsN02 BEParacetamol-AlvedonFluidN02 BEParacetamol-AcetamolTabletsN02 BEParacetamolParacetamol sodiumAcetasodIntravenousN02 BEParacetamolParacetamol hydroclorideAceclorideUnspecifiedN02 BAAcetylsalicylic acid-AspirinTabletsMagnus Wallberg.

6 UMCA ccess to the WHO-DDMagnus Wallberg, UMCHow to access the WHO-DDWHO-DD is available in several ways As textfiles to download and load in local tools Requires in-depthtechnical knowledge of the WHO DD structure Via online tools: Integrated in VigiSearch Integrated in VigiFlow WHO DD browser The methods for access is somewhat different depending on the needs for each specific toolMagnus Wallberg, UMCM agnus Wallberg, UMCWHO drug Dictionary -VigiSearch The WHO drug Dictionary is available via VigiSearch Only medicinal products reported on ICSRs available VigiSearch is up to date with all medicinal products occuring on the reports within VigiBase Updated together with the data in VigiSearch on a monthly basisWHO drug Dictionary -VigiSearchMagnus Wallberg, UMCWHO drug Dictionary -VigiSearchMagnus Wallberg, UMCM agnus Wallberg, UMCYou are now ready to perform a search based on your selectionMagnus Wallberg, UMCM agnus Wallberg.

7 UMCWHO drug Dictionary -VigiFlow The WHO drug Dictionary is available via VigiFlow Amount of data depends on agreement with National Authority VigiFlow is up to date with the latest WHO drug Dictionary content Usually updated with new entries once per weekMagnus Wallberg, UMCM agnus Wallberg, UMCM agnus Wallberg, UMCThis is the level to select when you onlyknow the tradename of the drug (or the substance).This is the level to select when you onlyknow the tradename of the drug (or the substance).Magnus Wallberg, UMCS elect this level when you know the tradename of the drug as well as ma-holder and/or this level when you know the tradename of the drug as well as ma-holder and/or Wallberg, UMCS elect this level when you know the tradename, ma-holder, country as wel as form and/or this level when you know the tradename, ma-holder, country as wel as form and/or drug Dictionary DD Browser The DD Browser is a web based tool primarily designed for the purpouse of searching the WHO-DD Unlike the browsers in VigiFlow and VigiSearch where they are integrated in the tools Provides a more powerful and flexible way of searching and looking at the data Here are a few screenshots but the DD Browser tool will not be presented in Wallberg, UMCM agnus Wallberg.

8 UMCE xample illustrating the search of single ingredientMagnus Wallberg, UMCE xample illustrating the search of single ingredientMagnus Wallberg, UMCE xample illustrating the search of single ingredientsMagnus Wallberg, UMCWHO Collaborating Centre for International drug MonitoringBox 1051, SE - 751 40 Uppsala Sweden Tel +46 18 65 60 60, Fax +46 18 65 60 88E-mail.