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1 Databases available for pharmacoepidemiology researches in Japan (information obtained from suvey answers as of October 2018). Hospital-based Insurance-based Pharmacy-based Others Japan Medical NHO NHO. CCT HCEI/RWD MID-NET MDV JMDC NDB JMDC JammNet MinaCare Medi-Scope Medi-Trend IQVIA NPA data JMIRI Research Institue . PFR NHWS NCD. NCDA MIA. ( Nihon-Chouzai). Database NHO ConvergenceCT Real World Data, Co., Pharmaceuticals and NHO Medical Data Vision JMDC Ministry of Health, JMDC JammNet MinaCare KYOWA KIKAKU Ltd. KYOWA KIKAKU Ltd. IQVIA Solutions Japan JMIRI Japan Medical ConvergenceCT SSRI, KH National Clinical administrator Japan Ltd. Medical Devices Co.,Ltd. Labour and Welfare Research Institue Japan Database Agency Co.

2 ,Ltd. ( Nihon- Chouzai). Database name NCDA ConvergenceCT RWD database Medical Information MIA EBM Provider JMDC Claims National Database of JMDC Claims JammNet database MinaCare Database Medi-Scope Medi-Trend IQVIA NPA data JMIRI Pharmacy NIHON CHOUZAI PFR NHWS : National National Clinical Global Research (RWD-DB) Database Network Database (Hospital- Health Insurance Database (Payer- Claims DB Pharmacy Claims DB Health and Wellness Database Network (CGRN) based) Claims and Specific based) Survey Database Health Checkups of Japan Contact information 700- cct-info@cct- wakaru- 700- medi- soken- cct-info@cct- p trend_helpdesk@kk- Web site URL /safety/mid- p/ p/stf/seisakunitsuite/b p/ ervice/omnibus/nhws/. unya/kenkou_iryou/iry ouhoken/reseputo/ind Database Overview General description of Clinical database Network to collect, de- A database that The medical Administrative Administrative Claims database Database of health Claims database Claims database The MinaCare Database based on Out of hospital cleims Pharmacy claims Pharmacy claims Claims database with Analysis service of NHWS collects data Multidiciplinary the database based on 61 NHO identify and integrates medical information Database database for inpatient database for inpatient consists of inpatients insurance claims and consists of using insurance Corporate insurance health insurance.

3 DB database collecting database contains extramural dispense Pharmacy claims. from patients in 10 registry platform hospital information summarize various information such as network system for and outpatient and outpatient and outpatients from specific health subscribers of programs database includes include of all Shops: about 870 extramural dispense extramural dispense claims and primary Information listed in countries. The data initially developed by systems data from medical electronic medical utilizing in safety consists of 143 NHO consists of 372 large multiple DPC/non checkups for employees'plural regularly updated data rezept(include dental shops claims from 7,500 records data ( QoL) from the Pharmacy claims includes more than surgery related institutions record, DPC, and assessment managed hospitals in Japan.)

4 (mainly tertiary) DPC hospitals preparation, Insurance programs of health checkups as rezept),except of Number of cleims: pharmacies patients visited one of is available. Reporting 165 disease areas professional societies claim data. by PMDA under the hospitals in Japan implementation and as complete well as medical and Organ transplant about 16 million nationwide. # of the Nihon-chozai without the time lag is and provides a variety in Japan. Currently Act on the evaluation of medical pharmaceutical patient and comment sheets / year prescriptions: 145 pharmacies. Nihon- possible. of metrics, such as managing nationwide Pharmaceuticals and cost optimization plan claims. The population field for all patients. million in 2017.

5 Chozai is the 2nd prevalence, diagnosis registries for various Medical Devices covered by the largest chain in Japan and treatment rates surgeries, Agency, consist of database includes and has 599 and more than 10,000 interventions, Hospital Information workers and their pharmacies other variables not pathology, as well as System (HIS) data, family members, and nationwide. mentioned here. multiple cancer DPC data and Claims the database covers a registries. Also data of 10 partner wide range of age maintains hospital organizations groups. based DPC / claims including 23 hospitals. database which can be used together with the registry data. Data source Electronic medical DPC (Fomat 1), DPC (Fomat 1), DPC (Fomat 1), DPC (Fomat 1), DPC (Fomat 1), Medical claim, Medical claim, DPC (E file), Medical claim, Pharmacy claim Pharmacy claim Pharmacy claim Pharmacy claim, Others Others DPC (Fomat 1), chart, DPC (E file), DPC (E file), DPC (E file), DPC (E file), DPC (E file), Pharmacy claim, Pharmacy claim, Medical claim, Pharmacy claim, Others DPC (E file), Lab test results, Medical claim, Medical claim, Medical claim Medical claim, Medical claim, Health checkup, Others Pharmacy claim, Others Medical claim, Inpatient vital Pharmacy claim, Electronic medical Others DPC (H file)

6 Others Health checkup, Registry Electronic medical chart, Others chart, Lab test results Lab test results Data source: Order entry data, DPC(F file)/DPC(D Eligibility information DPC Receipt Dental claim DPC rezept ,Dental Extramural dispense Patient survey Out-of-hospital Patient-reported Data are registered Others, notes Laboratory test file)/DPC claims/blood rezept claims dispensing record Information based on records results, DPC data, test data from patient record, Claim data of *Blood test data is discharge summaries, collaborative medical limited to some operative records, and institutions (Tohoku hospitals and numeric laboratory records. Univ., Chiba Univ., results. Univ Tokyo, Hamamatsu Med., Kagawa Univ.)

7 , Kyushu Univ., Saga . Univ., Kitazato . Group., NTT Group., Tokushukai Group). Data period: Jan-16 Depending on Depending on Jan-09 Apr-10 Apr-08 Apr-14 Apr-09 Jan-05 Apr-08 Apr-08 Jan-10 Oct-15 Jan-15 Jan-06 Apr-01 Most recent 2 years 1998 (2008 for 2011- Starting year/month each institution when each institution Japanese data). introduced electronic medical chart Data period: Previous day Depending on Depending on Sep-18 Jul-18 Jul-18 Apr-18 Jun-18 Mar-17 Aug-18 Sep-18 1 month ago Sep-18 Api 2001 Previous day 2017 2017. Latest year/month each institution when each institution introduced electronic medical chart Data period: some hospitals Mainly from April mainly from Jan 2013 (3 years data period Part of the data is 2018 Data will be 2011-2017.

8 Notes 2010 by WEB Service) available from April available in January, 2008. 2019. Size Number of unique 1,600,000 About 3,600,000 approx. 20 million currently approx. 20,000,000 About 24,900,000 approx. million approx. million approx. million approx. million Unique patient Unknown 13,600,000 About 3,000,000 2 million Around 10,000,000. identifiers >4,000,000(Apr-18) (population-based) approx. million cases Annual number of About 300,000 million approx. 2,500,000 About 10,220,000 approx. million approx. 4 million approx. million approx. million Unique patient approx. 29,760,000 11,000,000 3,090,000 About 1,600,000 Japan Data 30,000 around 1,700,000. unique identifiers approx. million (Both projected and cases (latest) non projected numbers are available.

9 Annual number of 2017 2016 Apr. 2017 ~ Mar. 2018 2017/04-2018/03 Aug 16 to Jul 17 Jan to Dec 2017 May2018 2016/4 2017/3 2017Y 2017 Oct. 2017 - Sep. 2018 3,090,000 (Apr 2017- 2017 2017. patients (latest): the Mar 2018). latest year or period % coverage of approx. of approx. 17% of about 8% of of DPC/non 4% of Japanese approx2% of of popuation <75 Covers of the approx. of total of annual of total of total of the adult Around 95% of all population Japnanese population population of Japan Japnanese population DPC hosipitals in population insurance programs yrs total population in extramural dispense prescription (Survey extramural dispense extramural dispense population cases of specific about Japan Japan (total claims (based on by Japan claims claims.)))

10 (Survey by surgeries /. 22% of total number population in 2016) Survey by Japan Pharmaceutical (Survey by Ministry Ministry of Health) interventions for large hospitals Pharmaceutical Association) of Health) performed in Japan Association). Annual N of About 200,000 million approx. 2,000,000 About 9,840,000 approx. million approx. million approx. million approx. million approx. million About 1,600,000 NA. outpatients (latest) (2017/04-2018/03) patiants Annual N of inpatients About 100,000 279,000 approx. 670,000 About1,930,000 approx. million approx. million approx. 40,000 approx. 90,000 approx. 192 thousand NA. (latest) (2017/04-2018/03). Annual N of treated About 64,000 226000 About 1,400,000 approx. approx.