Transcription of 2章 药物代谢动力学 - ahmu.edu.cn
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2章 药物代谢动力学 - ahmu.edu.cn
2 . Pharmacokinetics Department of pharmacology, Anhui medical university . (disposition) . (absorption). (distribution). (metabolism). (excretion).. Department of pharmacology, Anhui medical university Pharmacokinetics Drug Administration Absorption Drug in Drug Drug Tissues of Concentration in Metabolism Distribution Systemic or Excreted Circulation Distribution Elimination Drug Concentration at Site of Action Pharmacodynamics Pharmacologic Effect Clinical Response Toxicity Efficacy Department of pharmacology, Anhui medical university . Drug transport Department of pharmacology, Anhui medical university .. Department of pharmacology, Anhui medical university .. Department of pharmacology, Anhui medical university 1.
Phase I 药物 结合 药物 无活性 活性↑或↓ 药物 亲脂 亲水 排 泄 氧化、还原、水解引入或 脱去基团(-OH、-CH 3、-NH 2、-SH) Phase II 结合 结合 内源性葡萄糖苷酸、硫酸 、醋酸与药物或I期反应代 谢物结合 代谢步骤和方式 3. 代谢(metabolism, 生物转化, Biotransformation)
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