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ACG Clinical Guideline: Evaluation of Abnormal …

18 The American Journal of GASTROENTEROLOGY VOLUME 112 | JANUARY 2017 guidelines INTRODUCTION Th e authors were invited by the Board of Trustees and Practice guidelines Committee of the American College of Gastroenterol-ogy to develop a practice guideline regarding the Evaluation of Abnormal liver chemistries. We used the following resources: 1 . A formal review and literature search of the world literature on MEDLINE and EMBASE databases dealing with the Evaluation of Abnormal liver chemistries, studies that dealt with normal or reference range for alanine aminotransferase (ALT) levels and what thresholds trigger an Evaluation for actionable liver disease. Studies detailing the relationship between ALT and nonalcoholic fatty liver disease, as well as studies assessing the signifi cance of elevated liver chemistries on overall mortality and morbidity. 2 . Guideline policies of the American College of Gastroenterology. 3 . Th e experience of the authors and independent reviewers, as well as communication with senior hepatologists across the United States with regard to the threshold for evaluating Abnormal liver chemistries.

The American Journal of GASTROENTEROLOGY). ...

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