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AUSTRALIAN PRODUCT INFORMATION APO …
PRODUCT INFORMATION Australia APO-Rosuvastatin 5 mg, 10 mg, 20 mg & 40 mg Tablets Page 1 APO-ROSUVASTATIN 5 MG, 10 MG, 20 MG & 40 MG TABLETS NAME OF THE MEDICINE Rosuvastatin calcium. Chemical Name: bis [(3R, 5S, 6E)-7-{4-(4-fluorophenyl)-2-[N-methyl(me thanesulfonyl)amino]-6-isopropyl-2-pyrim idin-5-yl}-3,5-dihydroxyhept-6-enoic acid] calcium salt Structural Formula: Molecular Formula: (C22H27FN3O6S)2Ca Molecular Weight: CAS Registry No: 147098-20-2 DESCRIPTION Rosuvastatin calcium is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor for the treatment of dyslipidaemia. Rosuvastatin calcium is an amorphous solid, which is slightly soluble in water ( mg/mL at 37 C) and has a pKa of Rosuvastatin calcium is the (3R, 5S, 6E) enantiomer.
5 myopathy and, rarely, rhabdomyolysis have been reported in patients treated with HMG-CoA reductase inhibitors including rosuvastatin.
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