Transcription of CHAPTER 18 MEDICINAL CHEMISTRY 18.1 …
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CHAPTER 18 MEDICINAL CHEMISTRY 18.1 …
CHAPTER 18 MEDICINAL IntroductionThe treatment of pain and disease is one of the most important goals ofhumankind. Since ancient times people have been using potions, natural productsand even the dust of mummies for the treatment of health problems. The healingeffects of remedies were often ascribed to spirits and mythical entities, but someof the herbal preparations did possess curative properties. In the 1800's scientistsbegan to investigate potions to determine what chemicals were present that couldcause the observed , the early days of MEDICINAL CHEMISTRY began with the study ofnaturally occurring materials that were effective in treating human disorders. Thestudies were tedious and required much sample purification and structuredetermination at a time when instrumental methods of analysis were , screening methods for chemical efficacy against disease had to bedeveloped so that humans were not used as AntibioticsModern therapy by chemicals, chemotherapy, is attributed to Paul Ehrlich(Germany, Nobel Prize in 1908) who synthesized the first antibiotic, an arseniccompound patterned after an azo dye that he found to stain a microorganismselectively.
CHAPTER 18 MEDICINAL CHEMISTRY 18.1 Introduction The treatment of pain and disease is one of the most important goals of humankind. Since ancient times people have been using potions, natural products
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