Guide to achieving reliable quantitative LC-MS measurements

Guide to achieving reliable quantitative LC-MS measurements Guide to achieving reliable quantitative LC-MS measurements RSC Analytical Methods Committee First Edition 2013. Editor Mike Sargent Contributors Ashley Sage Acknowledgements Celine Wolff This Guide has been prepared with the Chris Mussell assistance of members of the AMC Mass Spectrometry Sub-Committee. David Neville Publication of the draft Guide with minor corrections was approved by the AMC at Gwyn Lord its meeting on 15 November 2013. Mansoor Saeed Production of this Guide was in part Rakesh Lad funded by the UK National Measurement System. Ruth Godfrey We are grateful to Agilent Ltd for Simon Hird permission to reproduce Figures , and Gareth Brenton for Figure Vicki Barwick First Edition 2013 This publication should be cited as: ISBN 978-0-948926-27-3.

Quantitative LC-MS Guide, 1st Ed. 2013 Page 1 1 Introduction Mass spectrometry is a very sensitive technique and is widely regarded as having good selectivity. However, in many applications it is necessary to isolate the target analyte from

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